[HTML][HTML] Gut microbiota: an important player in type 2 diabetes mellitus

Z Zhou, B Sun, D Yu, C Zhu - Frontiers in cellular and infection …, 2022 - frontiersin.org
Type 2 diabetes mellitus (T2DM) is one of the common metabolic diseases in the world. Due
to the rise in morbidity and mortality, it has become a global health problem. To date, T2DM …

Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 …

F Vanweert, P Schrauwen, E Phielix - Nutrition & diabetes, 2022 - nature.com
Branched-chain amino acid (BCAA) catabolism has been considered to have an emerging
role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D) …

Branched-chain amino acids: catabolism in skeletal muscle and implications for muscle and whole-body metabolism

G Mann, S Mora, G Madu, OAJ Adegoke - Frontiers in Physiology, 2021 - frontiersin.org
Branched-chain amino acids (BCAAs) are critical for skeletal muscle and whole-body
anabolism and energy homeostasis. They also serve as signaling molecules, for example …

A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes

F Vanweert, M Neinast, EE Tapia… - Nature …, 2022 - nature.com
Elevations in plasma branched-chain amino acid (BCAA) levels associate with insulin
resistance and type 2 diabetes (T2D). Pre-clinical models suggest that lowering BCAA levels …

Role of branched-chain amino acid metabolism in type 2 diabetes, obesity, cardiovascular disease and non-alcoholic fatty liver disease

P Cuomo, R Capparelli, A Iannelli… - International Journal of …, 2022 - mdpi.com
Branched-chain amino acids (BCAAs) include leucine, isoleucine, and valine. Mammalians
cannot synthesize these amino acids de novo and must acquire them through their diet …

Branched-chain amino acids and insulin resistance, from protein supply to diet-induced obesity

JP De Bandt, X Coumoul, R Barouki - Nutrients, 2022 - mdpi.com
For more than a decade, there has been a wide debate about the branched-chain amino
acids (BCAA) leucine, valine, and isoleucine, with, on the one hand, the supporters of their …

Mulberry leaf water extract alleviates type 2 diabetes in mice via modulating gut microbiota‐host co‐metabolism of branched‐chain amino acid

X Zheng, D Li, Y Li, Y Chen, Y Zhao, S Ji… - Phytotherapy …, 2023 - Wiley Online Library
Elevations in circling branched‐chain amino acids (BCAAs) levels associated with insulin
resistance and type 2 diabetes mellitus (T2DM). Morus alba L. water extracts (MLE) show …

Regulation of macronutrients in insulin resistance and glucose homeostasis during type 2 diabetes mellitus

W Yang, W Jiang, S Guo - Nutrients, 2023 - mdpi.com
Insulin resistance is an important feature of metabolic syndrome and a precursor of type 2
diabetes mellitus (T2DM). Overnutrition-induced obesity is a major risk factor for the …

[HTML][HTML] The contradictory role of branched-chain amino acids in lifespan and insulin resistance

H Yao, K Li, J Wei, Y Lin, Y Liu - Frontiers in Nutrition, 2023 - frontiersin.org
Branched-chain amino acids (BCAAs; a mixture of leucine, valine and isoleucine) have
important regulatory effects on glucose and lipid metabolism, protein synthesis and …

Effect of β2-agonist treatment on insulin-stimulated peripheral glucose disposal in healthy men in a randomised placebo-controlled trial

SMM van Beek, YMH Bruls, F Vanweert… - Nature …, 2023 - nature.com
Abstract β2-agonist treatment improves skeletal muscle glucose uptake and whole-body
glucose homeostasis in rodents, likely via mTORC2-mediated signalling. However, human …