Small molecule metabolites: discovery of biomarkers and therapeutic targets
S Qiu, Y Cai, H Yao, C Lin, Y Xie, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …
Re-evaluation of Diadenosine Tetraphosphate (Ap4A) From a Stress Metabolite to Bona Fide Secondary Messenger
F Ferguson, AG McLennan, MD Urbaniak… - Frontiers in Molecular …, 2020 - frontiersin.org
Cellular homeostasis requires adaption to environmental stress. In response to various
environmental and genotoxic stresses, all cells produce dinucleoside polyphosphates …
environmental and genotoxic stresses, all cells produce dinucleoside polyphosphates …
If the 5'cap fits (wear it)–Non-canonical RNA capping
JF Potužník, H Cahova - RNA biology, 2024 - Taylor & Francis
ABSTRACT RNA capping is a prominent RNA modification that influences RNA stability,
metabolism, and function. While it was long limited to the study of the most abundant …
metabolism, and function. While it was long limited to the study of the most abundant …
The expanding field of non-canonical RNA capping: new enzymes and mechanisms
J Wiedermannová, C Julius… - Royal Society Open …, 2021 - royalsocietypublishing.org
Recent years witnessed the discovery of ubiquitous and diverse 5′-end RNA cap-like
modifications in prokaryotes as well as in eukaryotes. These non-canonical caps include …
modifications in prokaryotes as well as in eukaryotes. These non-canonical caps include …
Preparation of RNAs with non-canonical 5′ ends using novel di-and trinucleotide reagents for co-transcriptional capping
A Depaix, E Grudzien-Nogalska… - Frontiers in Molecular …, 2022 - frontiersin.org
Many eukaryotic and some bacterial RNAs are modified at the 5′ end by the addition of cap
structures. In addition to the classic 7-methylguanosine 5′ cap in eukaryotic mRNA, several …
structures. In addition to the classic 7-methylguanosine 5′ cap in eukaryotic mRNA, several …
Remdesivir triphosphate is a valid substrate to initiate synthesis of DNA primers by human PrimPol
M Jiménez-Juliana, MI Martínez-Jiménez, L Blanco - DNA repair, 2024 - Elsevier
Remdesivir is a broad-spectrum antiviral drug which has been approved to treat COVID-19.
Remdesivir is in fact a prodrug, which is metabolized in vivo into the active form remdesivir …
Remdesivir is in fact a prodrug, which is metabolized in vivo into the active form remdesivir …
Staphylococcus aureus Small RNAs Possess Dephospho-CoA 5′-Caps, but No CoAlation Marks
C Löcherer, N Bühler, P Lafrenz, A Jäschke - Non-coding RNA, 2022 - mdpi.com
Novel features of coenzyme A (CoA) and its precursor, 3′-dephospho-CoA (dpCoA),
recently became evident. dpCoA was found to attach to 5′-ends of small ribonucleic acids …
recently became evident. dpCoA was found to attach to 5′-ends of small ribonucleic acids …