The development of new ion-activation/dissociation methods continues to be one of the most
active areas of mass spectrometry owing to the broad applications of tandem mass …

For more than two decades, mass spectrometry has been a central technology for
proteomics research. During this time, the use of chemical reactions to introduce tags for …

Chemoproteomic profiling of sulfhydryl-containing proteins has consistently been an
attractive research hotspot. However, there remains a dearth of probes that are specifically …

Confident protein identifications derived from high-throughput bottom-up and top-down
proteomics workflows depend on acquisition of thousands of tandem mass spectrometry …

The study of protein oxidation remains a challenge despite the biomedical interest in reliable
biomarkers of oxidative stress. This is particularly true for carbonylations although, recently …

Despite the successful application of tandem mass tags (TMT) for peptide quantitation,
missing reporter ions in higher energy collisional dissociation (HCD) spectra remains a …

Phenyl-1, 2-benzoselenazol-3 (2H)-one (ebselen) is a classical mimic of glutathione
peroxidase (GPx). Thioredoxin interaction endows ebselen attractive biological functions …

Thanks to comprehensive and unbiased sampling of all precursor ions, the interest to move
toward bottom-up proteomic with data-independent acquisition (DIA) is continuously …

Cysteine (Cys) is prone to diverse post-translational modifications in proteins, including
oxidation into sulfenic acid (Cys-SOH) by reactive oxygen species generated under …

N-terminal derivatization of peptides with the chromogenic reagent 4-acetamido-4-
isothiocyanatostilbene-2, 2-disulfonic acid (SITS) is demonstrated to enhance the efficiency …