Hedgehog signaling in cancer: a prospective therapeutic target for eradicating cancer stem cells
The Hedgehog (Hh) pathway is a signaling cascade that plays a crucial role in many
fundamental processes, including embryonic development and tissue homeostasis …
fundamental processes, including embryonic development and tissue homeostasis …
New insights into TCR β-selection
T cell receptor (TCR) β-selection (herein referred to as β-selection) is a pivotal checkpoint in
mammalian T cell development when immature CD4–CD8–T-cells (thymocytes) express pre …
mammalian T cell development when immature CD4–CD8–T-cells (thymocytes) express pre …
Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells
The zinc finger protein ZFYVE21 is involved in immune signaling. Using humanized mouse
models, primary human cells, and patient samples, we identified a T cell–autonomous role …
models, primary human cells, and patient samples, we identified a T cell–autonomous role …
Targeting hedgehog in hematologic malignancy
DA Irvine, M Copland - Blood, The Journal of the American …, 2012 - ashpublications.org
The Hedgehog pathway is a critical mediator of embryonic patterning and organ
development, including hematopoiesis. It influences stem cell fate, differentiation …
development, including hematopoiesis. It influences stem cell fate, differentiation …
Hedgehog signaling controls T cell killing at the immunological synapse
The centrosome is essential for cytotoxic T lymphocyte (CTL) function, contacting the plasma
membrane and directing cytotoxic granules for secretion at the immunological synapse …
membrane and directing cytotoxic granules for secretion at the immunological synapse …
Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancer
Host responses to tumor cells include tumor suppressing or promoting mechanisms. We
sought to detail the effect of Hedgehog (Hh) pathway inhibition on the composition of the …
sought to detail the effect of Hedgehog (Hh) pathway inhibition on the composition of the …
Understanding the roles of the hedgehog signaling pathway during T-cell lymphopoiesis and in T-cell acute lymphoblastic leukemia (T-ALL)
AM Martelli, F Paganelli, S Truocchio… - International journal of …, 2023 - mdpi.com
The Hedgehog (HH) signaling network is one of the main regulators of invertebrate and
vertebrate embryonic development. Along with other networks, such as NOTCH and WNT …
vertebrate embryonic development. Along with other networks, such as NOTCH and WNT …
Endocrine regulation on bone by thyroid
S Zhu, Y Pang, J Xu, X Chen, C Zhang, B Wu… - Frontiers in …, 2022 - frontiersin.org
Background As an endocrine organ, the thyroid acts on the entire body by secreting a series
of hormones, and bone is one of the main target organs of the thyroid. Summary This review …
of hormones, and bone is one of the main target organs of the thyroid. Summary This review …
Sonic Hedgehog signaling limits atopic dermatitis via Gli2-driven immune regulation
E Papaioannou, DC Yánez, S Ross… - The Journal of …, 2019 - Am Soc Clin Investig
Hedgehog (Hh) proteins regulate development and tissue homeostasis, but their role in
atopic dermatitis (AD) remains unknown. We found that on induction of mouse AD, Sonic …
atopic dermatitis (AD) remains unknown. We found that on induction of mouse AD, Sonic …
Tissue-derived hedgehog proteins modulate Th differentiation and disease
Genome-wide association studies of complex immune-mediated diseases have indicated
that many genetic factors, each with individual low risk, contribute to overall disease. It is …
that many genetic factors, each with individual low risk, contribute to overall disease. It is …