Maintenance therapy for acute lymphoblastic leukemia: basic science and clinical translations
Maintenance therapy (MT) with oral methotrexate (MTX) and 6-mercaptopurine (6-MP) is
essential for the cure of acute lymphoblastic leukemia (ALL). MTX and 6-MP interfere with …
essential for the cure of acute lymphoblastic leukemia (ALL). MTX and 6-MP interfere with …
Pharmacogenomics in the clinic
MV Relling, WE Evans - Nature, 2015 - nature.com
After decades of discovery, inherited variations have been identified in approximately 20
genes that affect about 80 medications and are actionable in the clinic. And some …
genes that affect about 80 medications and are actionable in the clinic. And some …
Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update
MV Relling, M Schwab, M Whirl‐Carrillo… - Clinical …, 2019 - Wiley Online Library
Thiopurine methyltransferase (TPMT) activity exhibits a monogenic codominant inheritance
and catabolizes thiopurines. TPMT variant alleles are associated with low enzyme activity …
and catabolizes thiopurines. TPMT variant alleles are associated with low enzyme activity …
Preemptive clinical pharmacogenetics implementation: current programs in five US medical centers
HM Dunnenberger, KR Crews… - Annual review of …, 2015 - annualreviews.org
Although the field of pharmacogenetics has existed for decades, practioners have been slow
to implement pharmacogenetic testing in clinical care. Numerous publications describe the …
to implement pharmacogenetic testing in clinical care. Numerous publications describe the …
Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing
Thiopurine methyltransferase (TPMT) activity exhibits monogenic co‐dominant inheritance,
with ethnic differences in the frequency of occurrence of variant alleles. With conventional …
with ethnic differences in the frequency of occurrence of variant alleles. With conventional …
Mercaptopurine/methotrexate maintenance therapy of childhood acute lymphoblastic leukemia: clinical facts and fiction
K Schmiegelow, SN Nielsen, TL Frandsen… - Journal of pediatric …, 2014 - journals.lww.com
The antileukemic mechanisms of 6-mercaptopurine (6MP) and methotrexate (MTX)
maintenance therapy are poorly understood, but the benefits of several years of …
maintenance therapy are poorly understood, but the benefits of several years of …
[图书][B] Textbook of pediatric rheumatology e-book
RE Petty, RM Laxer, CB Lindsley, L Wedderburn… - 2020 - books.google.com
Offering up-to-date, comprehensive coverage of disease progression, diagnosis,
management, and prognosis, Textbook of Pediatric Rheumatology is the definitive reference …
management, and prognosis, Textbook of Pediatric Rheumatology is the definitive reference …
ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C
Chronic infection with the hepatitis C virus (HCV) affects 170 million people worldwide and
is an important cause of liver-related morbidity and mortality. The standard of care therapy …
is an important cause of liver-related morbidity and mortality. The standard of care therapy …
Pharmacogenomics and individualized medicine: translating science into practice
Research on genes and medications has advanced our understanding of the genetic basis
of individual drug responses. The aim of pharmacogenomics is to develop strategies for …
of individual drug responses. The aim of pharmacogenomics is to develop strategies for …
Cancer pharmacogenomics: strategies and challenges
Genetic variation influences the response of an individual to drug treatments. Understanding
this variation has the potential to make therapy safer and more effective by determining …
this variation has the potential to make therapy safer and more effective by determining …