Sepsis, a life threating syndrome characterized by organ failure after infection, is the most
common cause of death in hospitalized patients. The treatment of sepsis is generally …

Innate immune cells can potentiate the response to reinfection through an innate form of
immunological memory known as trained immunity. The potential of this fast-acting …

Microbial products, such as lipopolysaccharide (LPS), can elicit efficient innate immune
responses against invading pathogens. However, priming with LPS can induce a form of …

Adaptation of the innate immune system has been recently acknowledged, explaining
sustained changes of innate immune responses. Such adaptation is termed trained …

Gout is a metabolic disease caused by the deposition of monosodium urate (MSU) crystals
inside joints, which leads to inflammation and tissue damage. Increased concentration of …

Inflammatory response plays an essential role in the resolution of infections. However,
inflammation can be detrimental to an organism and cause irreparable damage. For …

For almost nearly a century, memory functions have been attributed only to acquired
immune cells. Lately, this paradigm has been challenged by an increasing number of …

Mast cells (MCs) constitute an essential cell lineage that participates in innate and adaptive
immune responses and whose phenotype and function are influenced by tissue-specific …

Early pregnancy is a complex and well-orchestrated differentiation process that involves all
the cellular elements of the fetal-maternal interface. Aberrant trophoblast-decidual …

The innate immunity is frequently accepted as a first line of relatively primitive defense
interfering with the pathogen invasion until the mechanisms of 'privileged'adaptive immunity …