New perspectives in diabetic neuropathy
Diabetes prevalence continues to climb with the aging population. Type 2 diabetes (T2D),
which constitutes most cases, is metabolically acquired. Diabetic peripheral neuropathy …
which constitutes most cases, is metabolically acquired. Diabetic peripheral neuropathy …
Mitochondrial calcium cycling in neuronal function and neurodegeneration
GC Walters, YM Usachev - Frontiers in cell and developmental …, 2023 - frontiersin.org
Mitochondria are essential for proper cellular function through their critical roles in ATP
synthesis, reactive oxygen species production, calcium (Ca2+) buffering, and apoptotic …
synthesis, reactive oxygen species production, calcium (Ca2+) buffering, and apoptotic …
Chlorpyrifos induces placental oxidative stress and barrier dysfunction by inducing mitochondrial apoptosis through the ERK/MAPK signaling pathway: in vitro and in …
J Bai, S Deng, H Fu, Q Yang, F Ren, S Zeng… - Science of The Total …, 2023 - Elsevier
Chlorpyrifos (CPF) is an organophosphorus pesticide that is widely used in agricultural
production and residential environments worldwide. In this study, we determined the harmful …
production and residential environments worldwide. In this study, we determined the harmful …
New therapeutic directions in type II diabetes and its complications: mitochondrial dynamics
S Wang, H Zhao, S Lin, Y Lv, Y Lin, Y Liu… - Frontiers in …, 2023 - frontiersin.org
As important organelles of energetic and metabolism, changes in the dynamic state of
mitochondria affect the homeostasis of cellular metabolism. Mitochondrial dynamics include …
mitochondria affect the homeostasis of cellular metabolism. Mitochondrial dynamics include …
Neuropathic pain; what we know and what we should do about it
PA Smith - Frontiers in Pain Research, 2023 - frontiersin.org
Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …
[HTML][HTML] MCU complex: Exploring emerging targets and mechanisms of mitochondrial physiology and pathology
J Wang, J Jiang, H Hu, L Chen - Journal of Advanced Research, 2024 - Elsevier
Background Globally, the onset and progression of multiple human diseases are associated
with mitochondrial dysfunction and dysregulation of Ca 2+ uptake dynamics mediated by the …
with mitochondrial dysfunction and dysregulation of Ca 2+ uptake dynamics mediated by the …
Integrative multiomic analyses of dorsal root ganglia in diabetic neuropathic pain using proteomics, phospho-proteomics, and metabolomics
Diabetic peripheral neuropathy (DPN) is characterized by spontaneous pain in the
extremities. Incidence of DPN continues to rise with the global diabetes epidemic. However …
extremities. Incidence of DPN continues to rise with the global diabetes epidemic. However …
Peripheral mechanisms of peripheral neuropathic pain
P Pacifico, JS Coy-Dibley, RJ Miller… - Frontiers in Molecular …, 2023 - frontiersin.org
Peripheral neuropathic pain (PNP), neuropathic pain that arises from a damage or disease
affecting the peripheral nervous system, is associated with an extremely large disease …
affecting the peripheral nervous system, is associated with an extremely large disease …
[HTML][HTML] Mitochondria and sensory processing in inflammatory and neuropathic pain
PSS Ribeiro, HLDM Willemen… - Frontiers in Pain …, 2022 - ncbi.nlm.nih.gov
Rheumatic diseases, such as osteoarthritis and rheumatoid arthritis, affect over 750 million
people worldwide and contribute to approximately 40% of chronic pain cases. Inflammation …
people worldwide and contribute to approximately 40% of chronic pain cases. Inflammation …
Mitochondria and sensory processing in inflammatory and neuropathic pain
P Silva Santos Ribeiro, HLDM Willemen… - Frontiers in Pain …, 2022 - frontiersin.org
Rheumatic diseases, such as osteoarthritis and rheumatoid arthritis, affect over 750 million
people worldwide and contribute to approximately 40% of chronic pain cases. Inflammation …
people worldwide and contribute to approximately 40% of chronic pain cases. Inflammation …