Unraveling the potential role of glutathione in multiple forms of cell death in cancer therapy

H Lv, C Zhen, J Liu, P Yang, L Hu… - Oxidative medicine and …, 2019 - Wiley Online Library
Glutathione is the principal intracellular antioxidant buffer against oxidative stress and
mainly exists in the forms of reduced glutathione (GSH) and oxidized glutathione (GSSG) …

Hydroxytyrosol: Bioavailability, toxicity, and clinical applications

M Robles-Almazan, M Pulido-Moran… - Food Research …, 2018 - Elsevier
Many beneficial properties have been attributed to the Mediterranean diet. Over the years,
researchers have attempted to learn which foods and which food components are …

Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells

Y Sun, Y Zheng, C Wang, Y Liu - Cell death & disease, 2018 - nature.com
Glutathione (GSH) protects against oxidative damage in many tissues, including retinal
pigment epithelium (RPE). Oxidative stress-mediated senescence and death of RPE and …

[HTML][HTML] Activation of Nrf2 signaling by natural products-can it alleviate diabetes?

M Matzinger, K Fischhuber, EH Heiss - Biotechnology advances, 2018 - Elsevier
Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …

Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino …

MH Sahani, E Itakura, N Mizushima - Autophagy, 2014 - Taylor & Francis
SQSTM1/p62 (sequestosome 1) is a multifunctional signaling molecule, involved in a variety
of cellular pathways. SQSTM1 is one of the best-known autophagic substrates, and is …

Polyphenol stilbenes: molecular mechanisms of defence against oxidative stress and aging‐related diseases

M Reinisalo, A Kårlund, A Koskela… - Oxidative medicine …, 2015 - Wiley Online Library
Numerous studies have highlighted the key roles of oxidative stress and inflammation in
aging‐related diseases such as obesity, type 2 diabetes, age‐related macular degeneration …

Nutrigenomics of extra‐virgin olive oil: A review

M Piroddi, A Albini, R Fabiani, L Giovannelli… - Biofactors, 2017 - Wiley Online Library
Nutrigenomics data on the functional components of olive oil are still sparse, but rapidly
increasing. Olive oil is the main source of fat and health‐promoting component of the …

Potential role of olive oil phenolic compounds in the prevention of neurodegenerative diseases

J Rodríguez-Morató, L Xicota, M Fitó, M Farré… - Molecules, 2015 - mdpi.com
Adherence to the Mediterranean Diet (MD) has been associated with a reduced incidence of
neurodegenerative diseases and better cognitive performance. Virgin olive oil, the main …

Evidence to support the anti-cancer effect of olive leaf extract and future directions

A Boss, KS Bishop, G Marlow, MPG Barnett… - Nutrients, 2016 - mdpi.com
The traditional Mediterranean diet (MD) is associated with long life and lower prevalence of
cardiovascular disease and cancers. The main components of this diet include high intake of …

[HTML][HTML] When autophagy meets cancer through p62/SQSTM1

A Puissant, N Fenouille, P Auberger - American journal of cancer …, 2012 - ncbi.nlm.nih.gov
Although p62/SQSTM1 was initially identified as an essential mediator of NFκB signaling,
several recent studies have also highlighted its important role at the crossroad between the …