[HTML][HTML] The evolving role of investigative toxicology in the pharmaceutical industry

F Pognan, M Beilmann, H Boonen, A Czich… - Nature reviews drug …, 2023 - nature.com
For decades, preclinical toxicology was essentially a descriptive discipline in which
treatment-related effects were carefully reported and used as a basis to calculate safety …

Applications of multi-omics technologies for crop improvement

Y Yang, MA Saand, L Huang, WB Abdelaal… - Frontiers in Plant …, 2021 - frontiersin.org
Multiple “omics” approaches have emerged as successful technologies for plant systems
over the last few decades. Advances in next-generation sequencing (NGS) have paved a …

Breeding and genomic approaches towards development of fusarium wilt resistance in chickpea

RK Yadav, MK Tripathi, S Tiwari, N Tripathi, R Asati… - Life, 2023 - mdpi.com
Chickpea is an important leguminous crop with potential to provide dietary proteins to both
humans and animals. It also ameliorates soil nitrogen through biological nitrogen fixation …

Metabolomics identifies shared lipid pathways in independent amyotrophic lateral sclerosis cohorts

SA Goutman, K Guo, MG Savelieff, A Patterson… - Brain, 2022 - academic.oup.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease lacking effective
treatments. This is due, in part, to a complex and incompletely understood pathophysiology …

A review of integrative omic approaches for understanding rice salt response mechanisms

MA Ullah, MR Abdullah-Zawawi, RA Zainal-Abidin… - Plants, 2022 - mdpi.com
Soil salinity is one of the most serious environmental challenges, posing a growing threat to
agriculture across the world. Soil salinity has a significant impact on rice growth …

Metabolomic profile of diabetic retinopathy: a GC-TOFMS-based approach using vitreous and aqueous humor

H Wang, J Fang, F Chen, Q Sun, X Xu, SH Lin, K Liu - Acta diabetologica, 2020 - Springer
Aim To identify the potential metabolite markers in diabetic retinopathy (DR) by using gas
chromatography coupled with time-of-flight mass spectrometry (GC-TOFMS). Methods GC …

[HTML][HTML] Exploring the roles of microorganisms and metabolites in the 30-year aging process of the dried pericarps of Citrus reticulata'Chachi'based on high …

F Wang, Y Hu, H Chen, L Chen, Y Liu - Food Research International, 2023 - Elsevier
GuangChenpi (GCP), the dried pericarps of Citrus reticulata'Chachi', has been consumed
daily as a food and dietary supplement in China for centuries. Its health benefits are …

Metabolomic-based studies of the intake of virgin olive oil: a comprehensive review

A Vazquez-Aguilar, E Sanchez-Rodriguez… - Metabolites, 2023 - mdpi.com
Virgin olive oil (VOO) is a high-value product from the Mediterranean diet. Some health and
nutritional benefits have been associated with its consumption, not only because of its …

Blood metabolomics analysis identifies differential serum metabolites in elite and sub-elite swimmers

M Cai, C Wu, C Jing, X Shen, M He, L Wang… - Frontiers in …, 2022 - frontiersin.org
Objective: Metabolites in body fluids, such as lactate, glucose, and creatinine, have been
measured by conventional methods to evaluate physical function and performance or …

Transcriptome and metabolome profiling of interspecific CSSLs reveals general and specific mechanisms of drought resistance in cotton

B Han, F Wang, Z Liu, L Chen, D Yue, W Sun… - Theoretical and Applied …, 2022 - Springer
In order to understand the molecular mechanism of cotton's response to drought during the
flowering and boll stage, transcriptomics and metabolomics were carried out for two …