A review of pharmacokinetic and pharmacological properties of asiaticoside, a major active constituent of Centella asiatica (L.) Urb.

Z He, Y Hu, Z Niu, K Zhong, T Liu, M Yang, L Ji… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Centella asiatica (L.) Urb., a potential medicinal plant, is
widely used in orient traditional medicine. Its major active constituents include asiaticoside …

Mapping of mTOR drug targets: Featured platforms for anti-cancer drug discovery

R Shams, Y Ito, H Miyatake - Pharmacology & Therapeutics, 2022 - Elsevier
The mammalian/mechanistic target of rapamycin (mTOR) is a regulatory protein kinase
involved in cell growth and proliferation. mTOR is usually assembled in two different …

Screening the possible anti-cancer constituents of Hibiscus rosa-sinensis flower to address mammalian target of rapamycin: an in silico molecular docking, HYDE …

HO Rasul, BK Aziz, DD Ghafour, A Kivrak - Molecular Diversity, 2023 - Springer
One of the most common malignancies diagnosed and the leading cause of death for cancer-
stricken women globally is breast cancer. The molecular subtype affects therapy options …

Discovery of potential mTOR inhibitors from Cichorium intybus to find new candidate drugs targeting the pathological protein related to the breast cancer: an …

HO Rasul, BK Aziz, DD Ghafour, A Kivrak - Molecular Diversity, 2023 - Springer
Breast cancer is the most common malignancy among women. It is a complex condition with
many subtypes based on the hormone receptor. The mammalian target of the rapamycin …

Resveratrol attenuates methamphetamine‐induced memory impairment via inhibition of oxidative stress and apoptosis in mice

Q Zeng, Q Xiong, M Zhou, X Tian, K Yue… - Journal of food …, 2021 - Wiley Online Library
Methamphetamine (METH) abuse produces serious neurotoxicity to the central nervous
system along with long‐term cognitive dysfunction. Resveratrol, a natural polyphenol, has …

Can Asiatic Acid from Centella asiatica Be a Potential Remedy in Cancer Therapy?—A Review

M Wiciński, A Fajkiel-Madajczyk, Z Kurant, S Gajewska… - Cancers, 2024 - mdpi.com
Simple Summary Cancer is the leading cause of death globally, prompting extensive
research into drugs that can enhance survival rates. The aim of our review was to assess the …

[HTML][HTML] Phloroglucinol prevents albumin glycation as well as diminishes ROS production, glycooxidative damage, nitrosative stress and inflammation in hepatocytes …

K Drygalski, E Fereniec, A Zalewska… - Biomedicine & …, 2021 - Elsevier
The treatment of diabetes mellitus aftermaths became one of medicine's most significant
therapeutical and financial issues in the XXI century. Most of which are related to protein …

Terminalia chebula extracts ameliorate methamphetamine-induced memory deficits via activating the ERK and Nrf2 pathway

Q Zeng, Q Xiong, K Lin, Z Liang, M Zhou, X Tian… - Brain research …, 2022 - Elsevier
As a psychoactive substance abused worldwide, methamphetamine (METH) abuse leads to
multiple neurodegenerative symptoms including memory deficits. Terminalia chebula retzius …

The health benefits of santol fruits and bioactive products isolated from Sandoricum koetjape Merr.: A scoping review

C Bailly - Journal of Food Biochemistry, 2022 - Wiley Online Library
The santol tree (Sandoricum koetjape Merr.) is largely distributed in Southeast Asia. It
produces useful timber and edible fruits, consumed fresh, and transformed. It has a wide …

Integrated network pharmacology and molecular docking to investigate the potential mechanism of Tufuling on Alzheimer's disease

Z Zhang, J Cheng, X Zhou, H Wu, B Zhang - Heliyon, 2024 - cell.com
Objective This study aimed to investigate the mechanism of Tu Fu Ling in treating
Alzheimer's disease (AD) using network pharmacology and molecular docking. Methods …