The ACSL4 network regulates cell death and autophagy in diseases
Simple Summary ACSL4 is an enzyme involved in the intracellular conversion of long-chain
fatty acids and coenzyme A into fatty-acid coenzymes. It plays a vital role in various …
fatty acids and coenzyme A into fatty-acid coenzymes. It plays a vital role in various …
[HTML][HTML] How to train your cell-Towards controlling phenotypes by harnessing the epigenome of Chinese hamster ovary production cell lines
N Marx, P Eisenhut, M Weinguny, G Klanert… - Biotechnology …, 2022 - Elsevier
Recent advances in omics technologies and the broad availability of big datasets have
revolutionized our understanding of Chinese hamster ovary cells in their role as the most …
revolutionized our understanding of Chinese hamster ovary cells in their role as the most …
Targeting group 3 medulloblastoma by the anti-PRUNE-1 and anti-LSD1/KDM1A epigenetic molecules
F Bibbò, F Asadzadeh, A Boccia, C Sorice… - International Journal of …, 2024 - mdpi.com
Medulloblastoma (MB) is a highly malignant childhood brain tumor. Group 3 MB (Gr3 MB) is
considered to have the most metastatic potential, and tailored therapies for Gr3 MB are …
considered to have the most metastatic potential, and tailored therapies for Gr3 MB are …
Mitochondrial membrane potential-enriched CHO host: a novel and powerful tool for improving biomanufacturing capability
With the aim of increasing protein productivity of Chinese hamster ovary (CHO) cells, we
sought to generate new CHO hosts with favorable biomanufacturing phenotypes and …
sought to generate new CHO hosts with favorable biomanufacturing phenotypes and …
Subcloning induces changes in the DNA‐methylation pattern of outgrowing Chinese hamster ovary cell colonies
M Weinguny, G Klanert, P Eisenhut, I Lee… - Biotechnology …, 2021 - Wiley Online Library
Chinese hamster ovary (CHO) cells are the most extensively used mammalian production
system for biologics intended for use in humans. A critical step in the establishment of …
system for biologics intended for use in humans. A critical step in the establishment of …
Chromosomal instability drives convergent and divergent evolution toward advantageous inherited traits in mammalian CHO bioproduction lineages
Genetic instability of Chinese hamster ovary (CHO) cells is implicated in production
inconsistency through poorly defined mechanisms. Using a multi-omics approach, we …
inconsistency through poorly defined mechanisms. Using a multi-omics approach, we …
From observational to actionable: rethinking omics in biologics production
HO Masson, KJ la Cour Karottki, J Tat, H Hefzi… - Trends in …, 2023 - cell.com
As the era of omics continues to expand with increasing ubiquity and success in both
academia and industry, omics-based experiments are becoming commonplace in industrial …
academia and industry, omics-based experiments are becoming commonplace in industrial …
Off-gas-based soft sensor for real-time monitoring of biomass and metabolism in Chinese hamster ovary cell continuous processes in single-use bioreactors
T Wallocha, O Popp - Processes, 2021 - mdpi.com
In mammalian cell culture, especially in pharmaceutical manufacturing and research,
biomass and metabolic monitoring are mandatory for various cell culture process steps to …
biomass and metabolic monitoring are mandatory for various cell culture process steps to …
[HTML][HTML] Identification of Cellular Signatures Associated with Chinese Hamster Ovary Cell Adaptation for Secretion of Antibodies.
The secretory capacity of Chinese hamster ovary (CHO) cells remains a fundamental
bottleneck in the manufacturing of protein-based therapeutics. Unconventional biological …
bottleneck in the manufacturing of protein-based therapeutics. Unconventional biological …
Key challenges in designing CHO chassis platforms
Following the success of and the high demand for recombinant protein-based therapeutics
during the last 25 years, the pharmaceutical industry has invested significantly in the …
during the last 25 years, the pharmaceutical industry has invested significantly in the …