Over the past decade, since it was first observed in vivo, there has been an explosion in
interest in the thin (∼ 500 nm), gel-like endothelial glycocalyx layer (EGL) that coats the …

Abstract CEREBRAL VASOSPASM IS a common, formidable, and potentially devastating
complication in patients who have sustained subarachnoid hemorrhage (SAH). Despite …

We have identified two distinct mechanisms initiating the adhesion of flowing platelets to
thrombogenic surfaces. The integrin α IIb β 3 promotes immediate arrest onto fibrinogen but …

Abstract SEROTONIN (5-hydroxytryptamine, 5-HT) is a monoaminergic neurotransmitter that
is believed to modulate numerous sensory, motor and behavioural processes in the …

SELECTINS tether to the blood vessel wall leukocytes that are flowing in the bloodstream
and support subsequent labile rolling interactions as the leukocytes are subjected to …

Leukocyte emigration into lymphatic tissues or inflammatory sites is regulated by the
expression of adhesion and signaling molecules (1). Binding of selectins to cell-surface …

Leukocyte recruitment into inflammatory sites is initiated by a reversible transient adhesive
contact with the endothelium called leukocyte rolling, which is thought to be mediated by the …

In the past, inflammation has been associated with infections and with the immune system.
But more recent evidence suggests that a much broader range of diseases have telltale …

Leukocyte trafficking into pulmonary tissue and airspaces is a critical component of the host
defense response. Activation and migration of polymorphonuclear leukocytes (PMNs) into …

Leukocyte adhesion through L-selectin to peripheral node addressin (PNAd, also known as
MECA-79 antigen), an L-selectin ligand expressed on high endothelial venules, has been …