Automated chemical oligosaccharide synthesis: novel approach to traditional challenges

M Panza, SG Pistorio, KJ Stine… - Chemical reviews, 2018 - ACS Publications
Advances in carbohydrate chemistry have certainly made common oligosaccharides much
more accessible. However, many current methods still rely heavily upon specialized …

Toward automated enzymatic synthesis of oligosaccharides

L Wen, G Edmunds, C Gibbons, J Zhang… - Chemical …, 2018 - ACS Publications
Oligosaccharides together with oligonucleotides and oligopeptides comprise the three major
classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide …

Automated glycan assembly: a perspective

M Guberman, PH Seeberger - Journal of the American Chemical …, 2019 - ACS Publications
The intrinsic complexity of carbohydrate structures has hampered access to pure glycans
and hence impeded progress in the glycosciences. Automated Glycan Assembly (AGA) has …

The logic of automated glycan assembly

PH Seeberger - Accounts of Chemical Research, 2015 - ACS Publications
Conspectus Carbohydrates are the most abundant biopolymers on earth and part of every
living creature. Glycans are essential as materials for nutrition and for information transfer in …

[HTML][HTML] Infant formula supplemented with biotics: current knowledge and future perspectives

S Salminen, B Stahl, G Vinderola, H Szajewska - Nutrients, 2020 - mdpi.com
Breastfeeding is natural and the optimal basis of infant nutrition and development, with many
benefits for maternal health. Human milk is a dynamic fluid fulfilling an infant's specific …

Production of human milk oligosaccharides by enzymatic and whole-cell microbial biotransformations

GA Sprenger, F Baumgärtner, C Albermann - Journal of biotechnology, 2017 - Elsevier
Human milk oligosaccharides (HMO) are almost unique constituents of breast milk and are
not found in appreciable amounts in cow milk. Due to several positive aspects of HMO for …

Enzymatic and chemoenzymatic synthesis of human milk oligosaccharides and derivatives

J Zheng, H Xu, J Fang, X Zhang - Carbohydrate Polymers, 2022 - Elsevier
Human milk oligosaccharides (HMOs) are complex glycans that are the third largest solid
component in human milk. It has attracted great interest in recent years due to their critical …

ISG15 in cancer: Beyond ubiquitin-like protein

HG Han, HW Moon, YJ Jeon - Cancer letters, 2018 - Elsevier
ISG15, the product of interferon (IFN)-stimulated gene 15, is the first identified ubiquitin-like
protein (Ubl), playing roles not only as an unconjugated form but also as a covalently …

[HTML][HTML] From lab bench to formulated ingredient: Characterization, production, and commercialization of human milk oligosaccharides

C Walsh, JA Lane, D van Sinderen… - Journal of Functional …, 2020 - Elsevier
Human milk oligosaccharides (HMOs) are known to positively influence infant health.
Extensive variation exists in the levels, diversity, and complexity of oligosaccharides in the …

[HTML][HTML] Automated glycan assembly as an enabling technology

A Pardo-Vargas, M Delbianco, PH Seeberger - Current opinion in chemical …, 2018 - Elsevier
Access to complex carbohydrates remains a limiting factor for the development of the
glycosciences. Automated glycan assembly (AGA) has accelerated and simplified the …