Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …

The belief that the vertebrate brain functions normally without classical lymphatic drainage
vessels has been held for many decades. On the contrary, new findings show that functional …

Abstract See Derry and Kent (doi: 10.1093/awx167) for a scientific commentary on this
article. The large variance in cognitive deterioration in subjects who test positive for amyloid …

Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in
2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild …

Worldwide there are over 46 million people living with dementia, and this number is
expected to double every 20 years reaching about 131 million by 2050. The cost to the …

Importance Older age, high levels of β-amyloid (Aβ), and the presence of the apolipoprotein
E (APOE) ε4 allele are risk factors for Alzheimer disease (AD). However, the extent to which …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterised by
amyloid beta (Aβ) plaques and tau neurofibrillary tangles in the brain. Human apolipoprotein …

Although APOE ε4 carriers are at substantially higher risk of developing Alzheimer's disease
than noncarriers, controversial evidence suggests that APOE ε4 might confer some …

Because our beliefs regarding our individuality, autonomy, and personhood are intimately
bound up with our brains, there is a public fascination with cerebral organoids, the “mini …

Background: The association between the apolipoprotein E (APOE) ε4 allele and high risk of
developing Alzheimer's disease (AD) dementia before the age of 80 has been recognized …