Antimicrobial peptides: An alternative to traditional antibiotics

S Ji, F An, T Zhang, M Lou, J Guo, K Liu, Y Zhu… - European Journal of …, 2024 - Elsevier
As antibiotic-resistant bacteria and genes continue to emerge, the identification of effective
alternatives to traditional antibiotics has become a pressing issue. Antimicrobial peptides …

Host defense peptide mimicking antimicrobial amino acid polymers and beyond: Design, synthesis and biomedical applications

Y Wu, K Chen, J Wang, M Chen, Y Chen, Y She… - Progress in Polymer …, 2023 - Elsevier
Microbial infections endanger human health and life. Conventional antibiotics has saved
countless human lives, however, is seriously challenged by the quick emergence of …

AMPlify: attentive deep learning model for discovery of novel antimicrobial peptides effective against WHO priority pathogens

C Li, D Sutherland, SA Hammond, C Yang, F Taho… - BMC genomics, 2022 - Springer
Background Antibiotic resistance is a growing global health concern prompting researchers
to seek alternatives to conventional antibiotics. Antimicrobial peptides (AMPs) are attracting …

[HTML][HTML] Functional biomaterials for comprehensive periodontitis therapy

J Luan, R Li, W Xu, H Sun, Q Li, D Wang… - … Pharmaceutica Sinica B, 2023 - Elsevier
Periodontitis is an inflammatory disease caused by bacterial infection directly, and the
dysregulation of host immune-inflammatory response finally destroys periodontal tissues …

Small molecular mimetics of antimicrobial peptides as a promising therapy to combat bacterial resistance

P Teng, H Shao, B Huang, J Xie, S Cui… - Journal of Medicinal …, 2023 - ACS Publications
Clinically, antibiotics are widely used to treat infectious diseases; however, excessive drug
abuse and overuse exacerbate the prevalence of drug-resistant bacterial pathogens …

[HTML][HTML] Strategies for lipid-based nanocomposites with potential activity against Mycobacterium tuberculosis: Microbial resistance challenge and drug delivery trends

AC Hatae, CA Roque-Borda, FR Pavan - OpenNano, 2023 - Elsevier
Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis, stands as an
immensely devastating and persistently relevant pathogen, claiming the lives of millions …

Development of bis-cyclic imidazolidine-4-one derivatives as potent antibacterial agents

M Wang, R Gao, M Zheng, P Sang, C Li… - Journal of medicinal …, 2020 - ACS Publications
Antibiotic resistance has emerged as one of the biggest public health concerns all over the
world. In an effort to combat bacterial infections, a series of imidazolidine-4-one derivatives …

Indolicidin revisited: biological activity, potential applications and perspectives of an antimicrobial peptide not yet fully explored

J Batista Araujo, G Sastre de Souza… - World Journal of …, 2022 - Springer
The emergence of multidrug-resistant bacteria, viruses and tumors is a serious threat to
public health. Among natural peptides, indolicidin, a 13-residue peptide belonging to the …

Highly stabilized α-helical coiled coils kill gram-negative bacteria by multicomplementary mechanisms under acidic condition

Z Lai, P Tan, Y Zhu, C Shao, A Shan… - ACS applied materials & …, 2019 - ACS Publications
Although antimicrobial peptides (AMPs) hold tremendous promise in overcoming the threats
of multidrug resistance, the main obstacle to successful therapeutic applications is their poor …

Liquid droplet formation and facile cytosolic translocation of IgG in the presence of attenuated cationic amphiphilic lytic peptides

T Iwata, H Hirose, K Sakamoto, Y Hirai… - Angewandte Chemie …, 2021 - Wiley Online Library
Fc region binding peptide conjugated with attenuated cationic amphiphilic lytic peptide L17E
trimer [FcB (L17E) 3] was designed for immunoglobulin G (IgG) delivery into cells. Particle …