Mitochondrial diseases are a group of inherited or acquired metabolic disorders caused by
mitochondrial dysfunction which may affect almost all the organs in the body and present at …

Intercellular signaling and component conduction are essential for multicellular organisms'
homeostasis, and mitochondrial transcellular transport is a key example of such cellular …

Mitochondrial loss and dysfunction drive T cell exhaustion, representing major barriers to
successful T cell-based immunotherapies. Here, we describe an innovative platform to …

Circulating cell-free mitochondrial DNA (cf-mtDNA) has been found in the plasma of
severely ill COVID-19 patients and is now known as a strong predictor of mortality. However …

Mitochondria control cellular functions through their metabolic role. Recent research that has
gained considerable attention is their ability to transfer between cells. This has the potential …

Endosymbioses have profoundly impacted the evolution of life and continue to shape the
ecology of a wide range of species. They give rise to new combinations of biochemical …

Glaucoma, an age-related neurodegenerative disease, is characterized by the death of
retinal ganglion cells (RGCs) and the corresponding loss of visual fields. This disease is the …

The strength of T cell receptor (TCR) stimulation and asymmetric distribution of fate
determinants are both implied to affect T cell differentiation. Here, we uncover asymmetric …

Mitochondrial diseases (MDs) are inherited genetic conditions characterized by pathogenic
mutations in nuclear DNA (nDNA) or mitochondrial DNA (mtDNA). Current therapies are still …

The epithelium covers, protects, and actively regulates various formations and cavities of the
human body. During embryonic development the assembly of the epithelium is crucial to the …