Despite the recent advancements of Cu catalysis for the cross-coupling of alkyl electrophiles
and the frequently proposed involvement of alkyl–Cu (III) complexes in such reactions, little …

Imines are a versatile class of chemicals with applications in pharmaceuticals and as
synthetic intermediates. While imines are conventionally synthesized via aldehyde-amine …

Data science is assuming a pivotal role in guiding reaction optimization and streamlining
experimental workloads in the evolving landscape of synthetic chemistry. A discipline-wide …

Copper-catalyzed coupling reactions of alkyl halides are believed to prominently involve
copper (II) species and alkyl radicals as pivotal intermediates, with their exact interaction …

Copper (III) fluorides are catalytically competent, yet elusive, intermediates in cross‐
coupling. The synthesis of [PPh4][CuIII (CF3) 3F](2), the first stable (isolable) CuIII− F, was …

Stereochemically controlled hydrogen bond donors play essential roles in the
pharmaceutical industry. Consequently, organic molecules that bear difluoromethyl (CF2H) …

Understanding the electronic structures of high‐valent metal complexes aids the
advancement of metal‐catalyzed cross coupling methodologies. A prototypical complex with …

A highly enantioselective formal hydroformylation of vinyl arenes enabled by copper hydride
(CuH) catalysis is reported. Key to the success of the method was the use of the mild Lewis …

The 3d transition metal-catalyzed enantioconvergent radical cross-coupling provides a
powerful tool for chiral molecule synthesis. In the classic mechanism, the bond formation …

The introduction of trifluoromethyl groups into organic molecules is of paramount importance
in modern synthetic chemistry and medicinal chemistry. While methods for constructing C …