The synergistic effects of curcumin and chemotherapeutic drugs in inhibiting metastatic, invasive and proliferative pathways

M Younes, R Mardirossian, L Rizk, T Fazlian… - Plants, 2022 - mdpi.com
Curcumin, the main phytochemical identified from the Curcuma longa L. family, is one of the
spices used in alternative medicine worldwide. It has exhibited a broad range of …

[HTML][HTML] Resveratrol and p53: How are they involved in CRC plasticity and apoptosis?

A Brockmueller, C Buhrmann… - Journal of Advanced …, 2024 - Elsevier
Background Colorectal cancer (CRC), which is mainly caused by epigenetic and lifestyle
factors, is very often associated with functional plasticity during its development. In addition …

[HTML][HTML] Investigating the physicochemical properties and pharmacokinetics of curcumin employing density functional theory and gastric protection

SW Qader, A Suvitha, M Ozdemir, I Benjamin… - Chemical Physics …, 2022 - Elsevier
The extraction, isolation as well as theoretical investigation of Cumcuma Xanthoriz (cxz)
molecule was evaluated to ascertain the physicochemical properties (pc) of the investigated …

Novel nano-sized metal complexes based on aceclofenac and glycine ligands: Synthesis, Characterization, molecular docking studies and their enhanced efficacy in …

SM Abd El-Hamid, SA Sadeek, NB Sadek… - Journal of Molecular …, 2023 - Elsevier
New nano metal complexes of Cu (II), Zr (IV), La (III), Th (IV) and U (VI) ions using Acecl as
primary ligand and glycine (Gly) as secondary ligand were synthesized and characterized …

Synthesis and chemopreventive potential of 5-fu/genistein hybrids on colorectal cancer cells

G Moreno-Quintero, W Castrillón-Lopez… - Pharmaceuticals, 2022 - mdpi.com
A series of 5-FU-Genistein hybrids were synthesized and their structures were elucidated by
spectroscopic analysis. The chemopreventive potential of these compounds was evaluated …

Unraveling cancer progression pathways and phytochemical therapeutic strategies for its management

V Sharma, AA Chaudhary, S Bawari, S Gupta… - Frontiers in …, 2024 - frontiersin.org
Cancer prevention is currently envisioned as a molecular-based approach to prevent
carcinogenesis in pre-cancerous stages, ie, dysplasia and carcinoma in situ. Cancer is the …

New Hybrid Scaffolds Based on 5-FU/Curcumin: Synthesis, Cytotoxic, Antiproliferative and Pro-Apoptotic Effect

G Moreno-Quintero, E Betancur-Zapata… - Pharmaceutics, 2023 - mdpi.com
A series of 5-FU-Curcumin hybrids were synthesized, and their structures were elucidated
by spectroscopic analysis. The synthesized hybrid compounds were evaluated in different …

[HTML][HTML] Validity and value of metabolic connectivity in mouse models of β-amyloid and tauopathy

F Ruch, J Gnörich, K Wind, M Köhler, A Zatcepin… - NeuroImage, 2024 - Elsevier
Among functional imaging methods, metabolic connectivity (MC) is increasingly used for
investigation of regional network changes to examine the pathophysiology of …

Resveratrol/Hydrazone hybrids: Synthesis and Chemopreventive activity against colorectal cancer cells

W Castrillón-López, A Herrera-Ramírez… - Pharmaceutics, 2022 - mdpi.com
A series of resveratrol/hydrazone hybrids were obtained and elucidated by spectroscopic
analysis. All compounds were evaluated against colorectal cancer cells (SW480 and …

Corn Silk Alleviates Paclitaxel–Induced Lung Toxicity in Rats.

AI Barakat, SH El-Nabi… - Journal of Medical and Life …, 2024 - journals.ekb.eg
Background: Corn silk is a yellow, silky substance that arises from the stigma of a female
flower at the tip of the corn cob in the maize plant. The chemotherapeutic drug paclitaxel …