Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …

Iron is an essential trace element for most organisms. A common way for bacteria to acquire
this nutrient is through the secretion of siderophores, which are secondary metabolites that …

Antibiotics are powerful drugs used in the treatment of bacterial infections. The inappropriate
use of these medicines has driven the dissemination of antibiotic resistance (AR) in most …

Since Hamilton published his seminal papers in 1964, our understanding of the importance
of cooperation for life on Earth has evolved beyond recognition. Early research was focused …

Iron is important for bacterial growth and survival, as it is a common co-factor in essential
enzymes. Although iron is very abundant in the earth crust, its bioavailability is low in most …

The rise of antimicrobial resistance (AMR) in bacterial pathogens is acknowledged by the
WHO as a major global health crisis. It is estimated that in 2050 annually up to 10 million …

Through the secretion of “public goods” molecules, microbes cooperatively exploit their
habitat. This is known as a major driver of the functioning of microbial communities …

Microbial secretions, such as metabolic enzymes, are often considered to be cooperative
public goods as they are costly to produce but can be exploited by others. They create …

The success of many viruses depends upon cooperative interactions between viral
genomes. However, whenever cooperation occurs, there is the potential for 'cheats' to …

Within-host adaptation is a hallmark of chronic bacterial infections, involving substantial
genomic changes. Recent large-scale genomic data from prolonged infections allow the …