Src Homology 2 (SH2) domains arose within metazoan signaling pathways and are involved
in protein regulation of multiple pleiotropic cascades. In signal transducer and activator of …

Efficient release of promoter-proximally paused RNA Pol II into productive elongation is
essential for gene expression. Recently, we reported that the Integrator complex can bind …

Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is a diagnosis of
exclusion, being the most common entity in mature T-cell neoplasms, and its molecular …

In the last decade, a novel molecular complex has been added to the RNA polymerase II-
mediated transcription machinery as one of the major components. This multiprotein …

Abstract tRNA are post-transcriptionally modified by chemical modifications that affect all
aspects of tRNA biology. An increasing number of mutations underlying human genetic …

Hyper-activated STAT5B variants are high value oncology targets for pharmacologic
intervention. STAT5BN642H, a frequently-occurring oncogenic driver mutation, promotes …

STAT5B is often mutated in hematopoietic malignancies. The most frequent STAT5B
mutation, Asp642His (N642H), has been found in over 90 leukemia and lymphoma patients …

HPV infection results in changes in host gene methylation which, in turn, are thought to
contribute to the neoplastic progression of HPV-associated cancers. The objective of this …

The integrator complex has been recently identified as a key regulator of RNA Polymerase II-
mediated transcription, with many functions including the processing of small nuclear RNAs …

Phospholipase C Gamma 1 (PLCG1) is frequently mutated in primary cutaneous T-cell
lymphoma (CTCL). This study functionally interrogated nine PLCG1 mutations (p. R48W, p …