The mechanisms of HBV-induced hepatocellular carcinoma

Y Jiang, Q Han, H Zhao, J Zhang - Journal of hepatocellular …, 2021 - Taylor & Francis
Hepatocellular carcinoma (HCC) is a common malignancy, and the hepatitis B virus (HBV) is
its major pathogenic factor. Over the past decades, it has been confirmed that HBV infection …

Hepatitis B viral protein HBx and the molecular mechanisms modulating the hallmarks of hepatocellular carcinoma: a comprehensive review

E Sivasudhan, N Blake, Z Lu, J Meng, R Rong - Cells, 2022 - mdpi.com
With 296 million cases estimated worldwide, chronic hepatitis B virus (HBV) infection is the
most common risk factor for hepatocellular carcinoma (HCC). HBV-encoded oncogene X …

Relevance of HBx for hepatitis B virus-associated pathogenesis

A Schollmeier, M Glitscher, E Hildt - International Journal of Molecular …, 2023 - mdpi.com
The hepatitis B virus (HBV) counts as a major global health problem, as it presents a
significant causative factor for liver-related morbidity and mortality. The development of …

Emerging therapies for chronic hepatitis B and the potential for a functional cure

ML Chang, YF Liaw - Drugs, 2023 - Springer
Worldwide, an estimated 296 million people are living with chronic hepatitis B virus (HBV)
infection, with a significant risk of morbidity and mortality. Current therapy with pegylated …

[HTML][HTML] Hepatitis B x antigen (HBx) is an important therapeutic target in the pathogenesis of hepatocellular carcinoma

A Medhat, A Arzumanyan, MA Feitelson - Oncotarget, 2021 - ncbi.nlm.nih.gov
Hepatitis B virus (HBV) is a human pathogen that has infected an estimated two billion
people worldwide. Despite the availability of highly efficacious vaccines, universal screening …

[HTML][HTML] Novel approaches to inhibition of HBsAg expression from cccDNA and chromosomal integrants: A review

AH Abdelwahed, BD Heineman… - Journal of Clinical and …, 2023 - ncbi.nlm.nih.gov
Hepatitis B virus (HBV) is a widely prevalent liver infection that can cause acute or chronic
hepatitis. Although current treatment modalities are highly effective in the suppression of …

Innate immunity and HBV persistence

C Chiale, AM Marchese, MD Robek - Current opinion in virology, 2021 - Elsevier
Hepatitis B virus (HBV) causes chronic infections that are associated with immune
dysfunction. Though T cell impairment is perhaps the most prominent immune change …

S100A8/A9-activated IFNγ+ NK cells trigger β-cell necroptosis in hepatitis B virus-associated liver cirrhosis

X Li, L Hong, MH Ru, R Cai, Y Meng, B Wang… - Cellular and Molecular …, 2024 - Springer
Background and aims Hepatitis B virus (HBV)-associated liver cirrhosis (LC), a common
condition with high incidence and mortality rates, is often associated with diabetes mellitus …

p38 activation and viral infection

L Wang, Z Xia, W Tang, Y Sun, Y Wu… - Expert Reviews in …, 2022 - cambridge.org
Viruses completely rely on the energy and metabolic systems of host cells for life activities.
Viral infections usually lead to cytopathic effects and host diseases. To date, there are still no …

Mesenchymal Stem Cell–Derived Exosomes in Various Chronic Liver Diseases: Hype or Hope?

L Zhu, Q Wang, M Guo, H Fang, T Li, Y Zhu… - Journal of …, 2024 - Taylor & Francis
Chronic liver conditions are associated with high mortality rates and have a large adverse
effect on human well-being as well as a significant financial burden. Currently, the only …