[HTML][HTML] Pancreatic β-cell dysfunction in type 2 diabetes: Implications of inflammation and oxidative stress
PV Dludla, SE Mabhida, K Ziqubu… - World journal of …, 2023 - ncbi.nlm.nih.gov
Insulin resistance and pancreatic β-cell dysfunction are major pathological mechanisms
implicated in the development and progression of type 2 diabetes (T2D). Beyond the …
implicated in the development and progression of type 2 diabetes (T2D). Beyond the …
[HTML][HTML] Mass cytometry imaging for the study of human diseases—applications and data analysis strategies
H Baharlou, NP Canete, AL Cunningham… - Frontiers in …, 2019 - frontiersin.org
High parameter imaging is an important tool in the life sciences for both discovery and
healthcare applications. Imaging Mass Cytometry (IMC) and Multiplexed Ion Beam Imaging …
healthcare applications. Imaging Mass Cytometry (IMC) and Multiplexed Ion Beam Imaging …
The opposing roles of CD4+ T cells in anti‐tumour immunity
Cancer immunotherapy focuses mainly on anti‐tumour activity of CD 8+ cytotoxic T
lymphocytes (CTL s). CTL s can directly kill all tumour cell types, provided they carry …
lymphocytes (CTL s). CTL s can directly kill all tumour cell types, provided they carry …
[HTML][HTML] New insights into the role of autoreactive CD8 T cells and cytokines in human type 1 diabetes
C Bender, S Rajendran, MG Von Herrath - Frontiers in endocrinology, 2021 - frontiersin.org
Since the establishment of the network for pancreatic organ donors with diabetes (nPOD),
we have gained unprecedented insight into the pathology of human type 1 diabetes. Many …
we have gained unprecedented insight into the pathology of human type 1 diabetes. Many …
[HTML][HTML] Neoepitopes in type 1 diabetes: etiological insights, biomarkers and therapeutic targets
T Rodriguez-Calvo, JD Johnson, L Overbergh… - Frontiers in …, 2021 - frontiersin.org
The mechanisms underlying type 1 diabetes (T1D) pathogenesis remain largely unknown.
While autoantibodies to pancreatic beta-cell antigens are often the first biological response …
While autoantibodies to pancreatic beta-cell antigens are often the first biological response …
Type 1 diabetes mellitus: Inflammation, mitophagy, and mitochondrial function
AV Blagov, VI Summerhill, VN Sukhorukov, MA Popov… - Mitochondrion, 2023 - Elsevier
Type 1 diabetes mellitus (T1DM) is a T-cell-mediated autoimmune disease characterized by
the damage of insulin-secreting β-cells in the pancreatic islets of Langerhans. To date, its …
the damage of insulin-secreting β-cells in the pancreatic islets of Langerhans. To date, its …
[HTML][HTML] PPARs at the crossroads of T cell differentiation and type 1 diabetes
F Riaz, P Wei, F Pan - Frontiers in Immunology, 2023 - frontiersin.org
T-cell-mediated autoimmune type 1 diabetes (T1D) is characterized by the immune-
mediated destruction of pancreatic beta cells (β-cells). The increasing prevalence of T1D …
mediated destruction of pancreatic beta cells (β-cells). The increasing prevalence of T1D …
Intratumoral immune triads are required for immunotherapy-mediated elimination of solid tumors
G Espinosa-Carrasco, E Chiu, A Scrivo, P Zumbo… - Cancer Cell, 2024 - cell.com
Tumor-specific CD8+ T cells are frequently dysfunctional and unable to halt tumor growth.
We investigated whether tumor-specific CD4+ T cells can be enlisted to overcome CD8+ T …
We investigated whether tumor-specific CD4+ T cells can be enlisted to overcome CD8+ T …
[HTML][HTML] Intratumoral immune triads are required for adoptive T cell therapy-mediated elimination of solid tumors
Tumor-reactive CD8 T cells found in cancer patients are frequently dysfunctional, unable to
halt tumor growth. Adoptive T cell transfer (ACT), the administration of large numbers of in …
halt tumor growth. Adoptive T cell transfer (ACT), the administration of large numbers of in …
The emerging roles of T helper cell subsets and cytokines in severe neutrophilic asthma
Q Chen, S Nian, Y Ye, D Liu, H Yu, H Xiong, B Pan… - Inflammation, 2022 - Springer
Neutrophilic asthma (NA) is a severe type of steroid resistant asthma, and so far the immune
mechanisms underlying NA are not clear. In this article, we performed a comprehensive …
mechanisms underlying NA are not clear. In this article, we performed a comprehensive …