Insulin resistance and pancreatic β-cell dysfunction are major pathological mechanisms
implicated in the development and progression of type 2 diabetes (T2D). Beyond the …

High parameter imaging is an important tool in the life sciences for both discovery and
healthcare applications. Imaging Mass Cytometry (IMC) and Multiplexed Ion Beam Imaging …

Cancer immunotherapy focuses mainly on anti‐tumour activity of CD 8+ cytotoxic T
lymphocytes (CTL s). CTL s can directly kill all tumour cell types, provided they carry …

Since the establishment of the network for pancreatic organ donors with diabetes (nPOD),
we have gained unprecedented insight into the pathology of human type 1 diabetes. Many …

The mechanisms underlying type 1 diabetes (T1D) pathogenesis remain largely unknown.
While autoantibodies to pancreatic beta-cell antigens are often the first biological response …

Type 1 diabetes mellitus (T1DM) is a T-cell-mediated autoimmune disease characterized by
the damage of insulin-secreting β-cells in the pancreatic islets of Langerhans. To date, its …

T-cell-mediated autoimmune type 1 diabetes (T1D) is characterized by the immune-
mediated destruction of pancreatic beta cells (β-cells). The increasing prevalence of T1D …

Tumor-specific CD8+ T cells are frequently dysfunctional and unable to halt tumor growth.
We investigated whether tumor-specific CD4+ T cells can be enlisted to overcome CD8+ T …

Tumor-reactive CD8 T cells found in cancer patients are frequently dysfunctional, unable to
halt tumor growth. Adoptive T cell transfer (ACT), the administration of large numbers of in …

Neutrophilic asthma (NA) is a severe type of steroid resistant asthma, and so far the immune
mechanisms underlying NA are not clear. In this article, we performed a comprehensive …