Background The remarkable growth of genome-wide association studies (GWAS) has
created a critical need to experimentally validate the disease-associated variants, 90% of …

Abstract Purpose of Review Genome-wide association studies have delineated the genetic
architecture of type 2 diabetes. While functional studies to identify target transcripts are …

Single-nucleus assay for transposase-accessible chromatin using sequencing (snATAC-
seq) creates new opportunities to dissect cell type–specific mechanisms of complex …

Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we
assess whether human β cell dysfunction induced by metabolic stress is reversible, evaluate …

Abstract Objective Type 2 diabetes (T2D) is a complex disease characterized by pancreatic
islet dysfunction, insulin resistance, and disruption of blood glucose levels. Genome-wide …

Aging is associated with complex molecular and cellular processes that are poorly
understood. Here we leveraged the Tabula Muris Senis single-cell RNA-seq data set to …

The genetic basis of disease has largely focused on coding regions. However, it has
become clear that a large proportion of the noncoding genome is functional and harbors …

Enhancers are a class of regulatory elements essential for precise spatio-temporal control of
gene expression during development and in terminally differentiated cells. This review …

The integrative analysis of high‐throughput reporter assays, machine learning, and profiles
of epigenomic chromatin state in a broad array of cells and tissues has the potential to …

Diabetes mellitus (DM) is a common metabolic disorder caused mainly by combining two
primary factors, which are (1) defects in insulin production by the pancreatic β-cells and (2) …