Plant secondary metabolites (SMs) are not only a useful array of natural products but also an
important part of plant defense system against pathogenic attacks and environmental …

Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Accumulating evidence has shown that cancer stem cells (CSCs) have a tumour-initiating
capacity and play crucial roles in tumour metastasis, relapse and chemo/radio-resistance …

Cancer stem cells (CSCs) have emerged as an underlying cause of cancer relapse and
resistance to treatment. Initially, biomarkers were used to identify and isolate distinct cell …

Successful anticancer chemotherapy requires targeting tumors efficiently and further
potential to eliminate cancer stem cell (CSC) subpopulations. Since CD44 is present on …

Despite its good initial response and significant survival benefit in patients with castration-
resistant prostate cancer (CRPC), taxane therapy inevitably encounters drug resistance in …

In the present study, we demonstrate that prolonged treatment by trastuzumab induced
resistance of NCI-N87 gastric cancer cells to trastuzumab. The resistant cells possessed …

Cancer incidence and mortality, metastasis, drug resistance and recurrence are still the
critical issues of oncological diseases. In this scenario, increasing scientific evidences …

Epithelial cancer patients not considered eligible for surgical resection frequently benefit
from chemotherapy. Chemotherapy is the treatment of cancer with one or combination of …

Malignant melanoma is a tumor characterized by a very high level of heterogeneity,
responsible for its malignant behavior and ability to escape from standard therapies. In this …