Abstract Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological
functions and pathological significances and play an important role in health and disease. In …

Introduction: There is a growing body of evidence to suggest that chronic silent inflammation
is a key feature in abdominal obesity, metabolic syndrome, type 2 diabetes (T2DM) and …

The bidirectional causality between kidney injury and inflammation remains an area of
unexpected discoveries. The last decade unraveled the molecular mechanisms of sterile …

In 2002, intracellular protein complexes known as the inflammasomes were discovered and
were shown to have a crucial role in the sensing of intracellular pathogen-and danger …

The interleukin (IL) 1 family of cytokines is noteworthy to have pleiotropic functions in
inflammation and acquired immunity. Over the last decades, several progresses have been …

Cytokines are the key mediators of inflammation in the course of autoimmune arthritis and
other immune-mediated diseases. Uncontrolled production of the pro-inflammatory …

Monoclonal antibodies (mAbs) are currently the largest and most dominant class of
therapeutic proteins. Inter-individual variability has been observed for several mAbs; …

Chorus is a small, operationally independent clinical development organization within Eli
Lilly and Company that specializes in drug development from candidate selection to clinical …

Interleukin 1 (IL-1) family is a group of cytokines with multiple local and systemic effects,
which regulates both innate and adaptive immune responses. Generally, most IL-1 family …

The pharmacokinetics of monoclonal antibodies is highly variable among patients. Several
factors of variability, referred to as covariates in pharmacokinetic modeling, are known to …