The aim of this work was to compare the anti-inflammatory and antioxidant effects of three
natural coumarins: 1, 2-benzopyrone, umbelliferone and esculetin. The antioxidant capacity …

Background Malignant pleural effusion (MPE) is the accumulation of fluid in the pleural
cavity as a result of malignancies affecting the lung, pleura and mediastinal lymph nodes …

Piperacillin, in combination with tazobactam is a common first-line antibiotic used for the
treatment of pleural infection, however its pleural pharmacokinetics and penetration has not …

The incidence of pleural infection is rising, and most clearly in the elderly, where it is
associated with the highest mortality. Despite notable limitations in animal models …

Pleural infection remains an everyday clinical challenge worldwide. Drainage of the infected
material and administration of antibiotics are the cornerstones of treatment. Despite a lack of …

This research aimed to optimise management of parapneumonic and malignant pleural
effusion (MPE). Results indicated that systemic corticosteroids are not beneficial vs placebo …

This PhD thesis explored aspects of pleural fluid drainage and antibiotic optimisation in
pleural infection. The benefit of intrapleural tissue plasminogen activator and …