Highlights•Drug discovery target portfolios are changing, with an increasing focus on
previously intractable targets.•In response to this, a range of new small-molecule modalities …

With the ambition to identify novel chemical starting points that can be further optimized into
small drug-like inhibitors of insulin-regulated aminopeptidase (IRAP) and serve as potential …

Biophysical affinity screening is increasingly being adopted as a high-throughput hit finding
technique in drug discovery. Automation is highly beneficial to high-throughput screening …

The severe acute respiratory syndrome-causing coronavirus 2 (SARS-CoV-2) papain-like
protease (PLpro) and main protease (Mpro) play an important role in viral replication events …

KRAS has been implicated in various cancers and has long been considered an
undruggable target. Recent advances in drug discovery have enabled new avenues for …