We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …

Sex differences have been well identified in many brain tumors. Even though glioblastoma
(GBM) is the most common primary malignant brain tumor in adults and has the worst …

Sex differences in the incidence and outcome of human disease are broadly recognized but,
in most cases, not sufficiently understood to enable sex-specific approaches to treatment …

Activation of the RAS/MAPK pathway is critical in melanoma. Melanoma can be grouped into
four molecular subtypes based on their main genetic driver: BRAF-mutant, NRAS-mutant …

Neurofibromatosis type 1 (NF1) is one of the most common brain tumor predisposition
syndromes, in which affected children are prone to the development of low-grade gliomas …

Sex differences in human health and disease can range from undetectable to profound.
Differences in brain tumor rates and outcome are evident in males and females throughout …

For the past decade, it has been recognized that pediatric low-grade gliomas (LGGs) and
glial-neuronal tumors carry distinct molecular alterations with resultant aberrant intracellular …

Although standard chemotherapy remains the mainstay of ONG treatment, newer
molecularly targeted therapies such as mitogen-activated protein kinase kinase inhibitors …

Glioblastoma multiforme (GBM) is among the most aggressive of human cancers. Although
differentiation therapy has been proposed as a potential approach to treat GBM, the …

Background Historically, the survival of patients with von Hippel-Lindau disease (vHL) has
been poorer than that of the general population. We aimed to determine whether the survival …