Estimating the effects of variants found in disease driver genes opens the door to
personalized therapeutic opportunities. Clinical associations and laboratory experiments …

Cancer cells display phenotypic equilibrium between the stem-like and differentiated states
during neoplastic homeostasis. The functional and mechanistic implications of this …

Recently, a new regulatory circuitry has been identified in which RNAs can crosstalk with
each other by competing for shared microRNAs. Such competing endogenous RNAs …

Identification and annotation of all the functional elements in the genome, including genes
and the regulatory sequences, is a fundamental challenge in genomics and computational …

A recent slew of ENCyclopedia Of DNA Elements (ENCODE) Consortium publications,
specifically the article signed by all Consortium members, put forward the idea that more …

The shear-responsive transcription factor Krüppel-like factor 2 (KLF2) is a critical regulator of
endothelial gene expression patterns induced by atheroprotective flow. As microRNAs …

Diabetic nephropathy (DN) as the primary cause of end-stage kidney disease is a common
complication of diabetes. Recent researches have shown the activation of nuclear factor …

Motivation: Promoter analysis is an essential step on the way to identify regulatory networks.
A prerequisite for successful promoter analysis is the prediction of potential transcription …

Background Autoimmune and autoinflammatory diseases involve interactions between
genetic risk factors and environmental triggers. We searched for a gene on chromosome …

Studies support the importance of microRNAs in physiological and pathological processes.
Here we describe the regulation and function of miR-29 in myogenesis and …