Liver regeneration and inflammation: from fundamental science to clinical applications

L Campana, H Esser, M Huch, S Forbes - Nature reviews Molecular cell …, 2021 - nature.com
Liver regeneration is a complex process involving the crosstalk of multiple cell types,
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …

Pathogenesis of acute respiratory distress syndrome

LA Huppert, MA Matthay… - Seminars in respiratory and …, 2019 - thieme-connect.com
Acute respiratory distress syndrome (ARDS) is a syndrome of acute respiratory failure
caused by noncardiogenic pulmonary edema. Despite five decades of basic and clinical …

Mitochondrial transfer via tunneling nanotubes is an important mechanism by which mesenchymal stem cells enhance macrophage phagocytosis in the in vitro and in …

MV Jackson, TJ Morrison, DF Doherty, DF McAuley… - Stem …, 2016 - academic.oup.com
Mesenchymal stromal cells (MSC) have been reported to improve bacterial clearance in
preclinical models of Acute Respiratory Distress Syndrome (ARDS) and sepsis. The …

Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial

JG Wilson, KD Liu, H Zhuo, L Caballero… - The Lancet …, 2015 - thelancet.com
Background No effective pharmacotherapy for acute respiratory distress syndrome (ARDS)
exists, and mortality remains high. Preclinical studies support the efficacy of mesenchymal …

Mesenchymal stem cell-derived extracellular vesicles for the treatment of acute respiratory distress syndrome

A Abraham, A Krasnodembskaya - Stem Cells Translational …, 2020 - academic.oup.com
Acute respiratory distress syndrome (ARDS) is a serious and potentially fatal acute
inflammatory lung condition which currently has no specific treatments targeting its …

Fifty Years of Research in ARDS.Cell-based Therapy for Acute Respiratory Distress Syndrome. Biology and Potential Therapeutic Value

JG Laffey, MA Matthay - American journal of respiratory and critical …, 2017 - atsjournals.org
On the basis of several preclinical studies, cell-based therapy has emerged as a potential
new therapeutic for acute respiratory distress syndrome (ARDS). Of the various cell-based …

Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis

J Walter, LB Ware, MA Matthay - The Lancet Respiratory Medicine, 2014 - thelancet.com
Multipotent mesenchymal stem (stromal) cells (MSCs) have shown promising therapeutic
effects in preclinical models of both acute respiratory distress syndrome (ARDS) and sepsis …

Lung extracellular matrix and fibroblast function

ES White - Annals of the American Thoracic Society, 2015 - atsjournals.org
Extracellular matrix (ECM) is a tissue-specific macromolecular structure that provides
physical support to tissues and is essential for normal organ function. In the lung, ECM plays …

Human mesenchymal stromal cells decrease the severity of acute lung injury induced by E. coli in the rat

J Devaney, S Horie, C Masterson, S Elliman, F Barry… - Thorax, 2015 - thorax.bmj.com
Background Mesenchymal stromal cells (MSCs) demonstrate considerable promise in
preclinical acute respiratory distress syndrome models. We wished to determine the efficacy …

[HTML][HTML] Mesenchymal stromal cells reduce evidence of lung injury in patients with ARDS

KD Wick, A Leligdowicz, H Zhuo, LB Ware… - JCI insight, 2021 - ncbi.nlm.nih.gov
BACKGROUND Whether airspace biomarkers add value to plasma biomarkers in studying
acute respiratory distress syndrome (ARDS) is not well understood. Mesenchymal stromal …