Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …

Depression is one of the most common comorbidities of many chronic medical diseases
including cancer and cardiovascular, metabolic, inflammatory and neurological disorders …

Early-life inflammation increases the risk for depression in later life. Here, we demonstrate
how early-life inflammation causes adolescent depressive-like symptoms: by altering the …

Depression is the leading cause of disability worldwide. Recent observations have revealed
an association between mood disorders and alterations of the intestinal microbiota. Here …

The hypothalamic-pituitary-adrenal (HPA) axis is involved in the pathophysiology of many
neuropsychiatric disorders. Increased HPA axis activity can be observed during chronic …

Depression and fatigue are conditions responsible for heavy global societal burden,
especially in patients already suffering from chronic diseases. These symptoms have been …

Since December 2019, the world has been experiencing the challenge of facing coronavirus
disease-19 (COVID-19), a severe infectious disease caused by the new coronavirus, SARS …

INTRODUCTION Depression is an episodic form of mental illness, yet the circuit-level
mechanisms driving the induction, remission, and recurrence of depressive episodes over …

Studies suggest that heightened peripheral inflammation contributes to the pathogenesis of
major depressive disorder. We investigated the effect of chronic social defeat stress, a …

Major depressive disorder (MDD) is a prevalent psychiatric disease that involves
malfunctions of different cell types in the brain. Accumulating studies started to reveal that …