Methods and compositions for treatment of a genetic condition
A Conway, GJ Cost, R DeKelver, EJ Rebar… - US Patent …, 2018 - Google Patents
Methods and compositions comprising single guide RNAs targeted to an endogenous
mammalian β globin gene (HBB), gamma globin gene (HBG1), B-cell lymphoma/leukemia …
mammalian β globin gene (HBB), gamma globin gene (HBG1), B-cell lymphoma/leukemia …
T cell modifying compounds and uses thereof
PD Gregory, MC Holmes - US Patent 9,597,357, 2017 - Google Patents
US9597357B2 - T cell modifying compounds and uses thereof - Google Patents US9597357B2
- T cell modifying compounds and uses thereof - Google Patents T cell modifying compounds …
- T cell modifying compounds and uses thereof - Google Patents T cell modifying compounds …
Methods and compositions for enhancing nuclease-mediated gene disruption
F Chen, Q Kang, T Wechsler - US Patent 10,227,610, 2019 - Google Patents
6, 794, 136 B1 9/2004 Eisenberg et al. 6, 824, 978 B1 11/2004 Cox, III et al. 6, 903, 185 B2
6/2005 Kim et al. 6, 933, 113 B2 8/2005 Case et al. 6, 974, 867 B2 12/2005 Wu et al. 6, 979 …
6/2005 Kim et al. 6, 933, 113 B2 8/2005 Case et al. 6, 974, 867 B2 12/2005 Wu et al. 6, 979 …
Delivery methods and compositions for nuclease-mediated genome engineering
PM Cannon, CM Exline, MC Holmes - US Patent 10,604,771, 2020 - Google Patents
6.242. 568 B 1 6/2001 Barbas, III et al.(57) ABSTRACT 6,410,248 B1 6/2002 Greisman et
al... 6,453.242 B1 9/2002 Eisenberg et al. Disclosed herein are methods and compositions …
al... 6,453.242 B1 9/2002 Eisenberg et al. Disclosed herein are methods and compositions …
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components
The invention provides for delivery, engineering and optimization of systems, methods, and
compositions for manipulation of sequences and/or activities of target sequences. Provided …
compositions for manipulation of sequences and/or activities of target sequences. Provided …
Targeted disruption of T cell receptor genes using talens
PD Gregory, MC Holmes, D Paschon, L Zhang… - US Patent …, 2018 - Google Patents
US9937207B2 - Targeted disruption of T cell receptor genes using talens - Google Patents
US9937207B2 - Targeted disruption of T cell receptor genes using talens - Google Patents …
US9937207B2 - Targeted disruption of T cell receptor genes using talens - Google Patents …
Methods and compositions for delivery of biologics
GJ Cost - US Patent 10,883,119, 2021 - Google Patents
US10883119B2 - Methods and compositions for delivery of biologics - Google Patents
US10883119B2 - Methods and compositions for delivery of biologics - Google Patents Methods …
US10883119B2 - Methods and compositions for delivery of biologics - Google Patents Methods …
Method of treating lysosomal storage diseases using nucleases and a transgene
EJ Rebar - US Patent 9,877,988, 2018 - Google Patents
6, 479, 626 B1 11/2002 Kim et al. 6, 503, 717 B2 1/2003 Case et al. 6, 534, 261 B1 3/2003
Cox, III et al. 6, 599, 692 B1 7/2003 Case et al. 6, 607, 882 B1 8/2003 Cox et al. 6, 689, 558 …
Cox, III et al. 6, 599, 692 B1 7/2003 Case et al. 6, 607, 882 B1 8/2003 Cox et al. 6, 689, 558 …
Compositions for linking DNA-binding domains and cleavage domains
D Paschon, L Zhang - US Patent 9,567,609, 2017 - Google Patents
US9567609B2 - Compositions for linking DNA-binding domains and cleavage domains -
Google Patents US9567609B2 - Compositions for linking DNA-binding domains and cleavage …
Google Patents US9567609B2 - Compositions for linking DNA-binding domains and cleavage …
Method of treating lysosomal storage diseases
EJ Rebar - US Patent 9,956,247, 2018 - Google Patents
Nucleases and methods of using these nucleases for insert ing a sequence encoding a
therapeutic protein such as an enzyme into a cell, thereby providing proteins or cell thera …
therapeutic protein such as an enzyme into a cell, thereby providing proteins or cell thera …