[HTML][HTML] Novel pyridine and pyrimidine derivatives as promising anticancer agents: A review

M Albratty, HA Alhazmi - Arabian Journal of Chemistry, 2022 - Elsevier
Pyridines and pyrimidines are the class of heterocyclic nitrogenous compounds having
plethora of applications in anticancer drug development. These synthetic sources serve as …

Selective COX-2 inhibitors as anticancer agents: a patent review (2018-2023)

M Mahboubi-Rabbani, AH Abdolghaffari… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction COX-2 is a crucial enzyme in the manufacture of prostaglandins. The enzyme's
metabolites might have an important function as regulators of the inflammatory response …

Synthesis, molecular docking study and anticancer activity of novel 1, 3, 4-oxadiazole derivatives as potential tubulin inhibitors

TA Yousef, AG Alhamzani, MM Abou-Krisha… - Heliyon, 2023 - cell.com
The current study reports on the synthesis and anticancer efficacy of novel oxadiazole
derivatives (8a-f) as tubulin polymerization inhibitors. NMR, mass, and elemental studies …

Synthesis, characterization, anticancer activity and molecular docking of metal complexes bearing a new Schiff base ligand

T Alorini, AN Al-Hakimi, I Daoud… - Journal of …, 2023 - Taylor & Francis
((E)-((4-(((E)-4-Nitrobenzylidene) amino) phenyl) imino) methyl) naphthalen-1-ol, was
synthesised followed by metalation with Fe (III), Co (III), Cu (II), Zn (II) and Ni (II) metals. The …

Novel Ag(I)-NHC complex: synthesis, in vitro cytotoxic activity, molecular docking, and quantum chemical studies

G Serdaroğlu, N Şahin, S Şahin-Bölükbaşı… - … für Naturforschung C, 2022 - degruyter.com
The importance of organometallic complexes in cancer biology has attracted attention in
recent years. In this paper, we look for the in vitro cytotoxic capability of novel benzimidazole …

Novel Ag (I)‐based 1, 2, 4‐Oxadiazole Complexes: Synthesis, X‐Ray Crystal Structure, and Biological Evaluation as Anticancer Candidates

MS Ayoup, RE Alashhab, SM Soliman… - Applied …, 2024 - Wiley Online Library
ABSTRACT The 3, 5‐diaryl‐1, 2, 4‐oxadiazole scaffolds 2 and 3 were synthesized and used
as ligands to obtain three novel Ag (I) complexes 4–6. The structure of the Ag (I) complexes …

Enzyme kinetics of deoxyuridine triphosphatase from Western corn rootworm

C Riera-Ruiz, H Moriyama - BMC Research Notes, 2023 - Springer
Abstract Objective The Western corn rootworm (WCR), Diabrotica virgifera virgifera, is a
highly adaptable insect pest that has evolved resistance to a variety of control strategies …

Dihydroartemisinin and zerumbone esters of ataluren and its analogs as anticancer agents and EGFR inhibitors

DQ Tran, NH Truong, THA Nguyen… - Journal of Chemical …, 2023 - journals.sagepub.com
In a five-step procedure, 18 new esters (20a–i and 21a–i) of ataluren and its analogs with
dihydroartemisinin and zerumbone were synthesized from methyl 3-cyanobenzoate. The …

Synthesis, biological evaluation, DNA binding, and molecular docking of hybrid 4, 6-dihydrazone pyrimidine derivatives as antitumor agents

H Lan, J Song, J Yuan, A Xing, D Zeng, Y Hao, Z Zhang… - Molecules, 2022 - mdpi.com
In the present paper, on the basis of molecular hybridization, a series of 4, 6-dihydrazone
pyrimidine derivatives containing the pyridine moiety were synthesized, structurally …

A Review on Synthetic Strategies for Useful Oxadiazole Derivatives in Psychological Disorders

S Saxena, R Kumar, A Mazumder… - Mini-Reviews in …, 2023 - ingentaconnect.com
Oxadiazole is a five-membered aromatic heterocyclic ring having two nitrogen and one
oxygen atom. Various isomeric forms have been reported for oxadiazole, such as 1, 3, 4 …