Mammalian preimplantation development, which is the period extending from fertilization to
implantation, results in the formation of a blastocyst with three distinct cell lineages. Only one …

The cytoskeleton—comprising actin filaments, microtubules and intermediate filaments—
serves instructive roles in regulating cell function and behaviour during development …

Neuronal polarization occurs shortly after mitosis. In neurons differentiating in vitro, axon
formation follows the segregation of growth-promoting activities to only one of the multiple …

Posttranslationally modified forms of tubulin accumulate in the subset of stabilized
microtubules (MTs) in cells but are not themselves involved in generating MT stability. We …

Abstract Knowledge on determination and differentiation in the mammalian embryo has not
kept pace with discoveries in other phyla. Current concepts overlook well-established …

The mammalian cell cytoskeleton consists of a diverse group of fibrillar elements that play a
pivotal role in mediating a number of digestive and nondigestive cell functions, including …

The asymmetric distribution of stable, posttranslationally modified microtubules (MTs)
contributes to the polarization of many cell types, yet the factors controlling the formation of …

BACKGROUND Assisted reproduction technology offers the opportunity to observe the very
early stages of human development. However, due to practical constraints, for decades …

In many organisms, like Caenorhabditis elegans and Drosophila melanogaster,
establishment of spatial patterns and definition of cell fate are driven by the segregation of …

Abstract Specification of the trophectoderm (TE) and inner cell mass (ICM) lineages in the
mouse blastocyst correlates with cell position, as TE derives from outer cells whereas ICM …