The JAK/STAT signaling pathway: from bench to clinic

X Hu, J Li, M Fu, X Zhao, W Wang - Signal transduction and targeted …, 2021 - nature.com
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

Recent updates in COVID-19 with emphasis on inhalation therapeutics: Nanostructured and targeting systems

AAH Abdellatif, HM Tawfeek, A Abdelfattah… - Journal of drug delivery …, 2021 - Elsevier
The current world health threat posed by the novel coronavirus disease of 2019 (COVID-19)
calls for the urgent development of effective therapeutic options. COVID-19 needs daunting …

[HTML][HTML] CD4+ T-cell subsets in autoimmune hepatitis: A review

H Chen, Z Han, Y Fan, L Chen, F Peng… - Hepatology …, 2023 - journals.lww.com
Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease that can lead to
hepatocyte destruction, inflammation, liver fibrosis, cirrhosis, and liver failure. The diagnosis …

Th1-related transcription factors and cytokines in systemic lupus erythematosus

YY Tang, DC Wang, YY Chen, WD Xu… - Frontiers in …, 2023 - frontiersin.org
Systemic lupus erythematosus (SLE) is an inflammatory disorder related to immunity
dysfunction. The Th1 cell family including Th1 cells, transcription factor T-bet, and related …

[PDF][PDF] Effects of Lactobacillus plantarum HFY15 on Lupus Nephritis in Mice by Regulation of the TGF-β1 Signaling Pathway

L Cheng, P Yao, H Wang, Q Yuan, X Wang… - Drug Design …, 2022 - Taylor & Francis
Objective In this study, the Lactobacillus plantarum HFY15 (LP-HFY15) strain isolated from
naturally fermented yak yogurt was investigated. An animal model of lupus nephritis was …

Identification of cytokines in benign and malignant thymus tumors: based on Mendelian randomization and proteomics

K Zhu, J Shi, R Yang, C Zhou, Z Liu - Frontiers in Endocrinology, 2024 - frontiersin.org
Objective The aim of this study was to identify potential causal cytokines in thymic
malignancies and benign tumors from the FinnGen database using Mendelian …

Curcumin and ustekinumab cotherapy alleviates induced psoriasis in rats through their antioxidant, anti-inflammatory, and antiproliferative effects

AM Mousa, FA Alhumaydhi, AAH Abdellatif… - Cutaneous and …, 2022 - Taylor & Francis
Introduction Psoriasis is a chronic multifactorial inflammatory disease that affects 3% of
people worldwide. Ustekinumab is a selective anti-IL-12/23 biologic that alleviates psoriasis …

[PDF][PDF] 中国药物作用靶点研究新进展(Ⅱ)

江振洲, 范书生, 刘家岐, 俞沁玮, 张陆勇 - 药学进展, 2022 - pps.cpu.edu.cn
通过检索2019—2020 年中国学者在国内外杂志上发表的关于恶性肿瘤, 心脑血管疾病,
神经退行性疾病, 精神障碍性疾病, 自身免疫性疾病, 感染性疾病, 代谢类疾病等重大疾病治疗靶 …

Lactobacillus plantarum CQPC02 intervenes in mouse lupus nephritis by regulating the NF-κB signaling pathway

Y Wu, X Zou, X Zhao, X Ma, X Yao, Y Wen - Brazilian Journal of …, 2023 - Springer
A strain of Lactobacillus plantarum CQPC02 (LP-CQPC02) isolated from naturally fermented
kimchi was utilized in this investigation. In order to construct an animal model of lupus …

Implementación de plataformas biosensoras ópticas basadas en nuevos elementos de reconocimiento selectivo para la monitorización de inmunosupresores en …

AB Glahn Martínez - 2023 - docta.ucm.es
En primer lugar, quiero mostrar mi agradecimiento a mis directoras de Tesis: la Prof. María
Cruz Moreno Bondi por su experiencia, su continua supervisión y discusión de los …