Hormonal and metabolic mechanisms of diabetes remission after gastrointestinal surgery

JP Thaler, DE Cummings - Endocrinology, 2009 - academic.oup.com
Bariatric surgery is the most effective available treatment for obesity. The most frequently
performed operation, Roux-en-Y gastric bypass (RYGB), causes profound weight loss and …

Bariatric surgery and cardiovascular risk factors: a scientific statement from the American Heart Association

P Poirier, MA Cornier, T Mazzone, S Stiles… - Circulation, 2011 - Am Heart Assoc
The rate of obesity is rising logarithmically, especially in those with severe obesity (body
mass index [BMI] 40 kg/m2). Cardiologists, endocrinologists, internists, family practitioners …

Gastric bypass vs sleeve gastrectomy for type 2 diabetes mellitus: a randomized controlled trial

WJ Lee, K Chong, KH Ser, YC Lee, SC Chen… - Archives of …, 2011 - jamanetwork.com
Objectives To determine the efficacies of 2 weight-reducing operations on diabetic control
and the role of duodenum exclusion. Design Double-blind randomized controlled trial …

Role of bile acids and GLP-1 in mediating the metabolic improvements of bariatric surgery

VL Albaugh, B Banan, J Antoun, Y Xiong, Y Guo, J Ping… - Gastroenterology, 2019 - Elsevier
Background & aims Bile diversion to the ileum (GB-IL) has strikingly similar metabolic and
satiating effects to Roux-en-Y gastric bypass (RYGB) in rodent obesity models. The …

Effects of gastric bypass surgery in patients with type 2 diabetes and only mild obesity

RV Cohen, JC Pinheiro, CA Schiavon, JE Salles… - Diabetes …, 2012 - Am Diabetes Assoc
OBJECTIVE Roux-en-Y gastric bypass (RYGB) ameliorates type 2 diabetes in severely
obese patients through mechanisms beyond just weight loss, and it may benefit less obese …

Metabolic surgery to treat type 2 diabetes: clinical outcomes and mechanisms of action

F Rubino, PR Schauer, LM Kaplan… - Annual review of …, 2010 - annualreviews.org
Several gastrointestinal (GI) operations that were designed to promote weight loss can
powerfully ameliorate type 2 diabetes mellitus (T2DM). Although T2DM is traditionally …

Bariatric surgery for weight loss and glycemic control in nonmorbidly obese adults with diabetes: a systematic review

M Maggard-Gibbons, M Maglione, M Livhits, B Ewing… - Jama, 2013 - jamanetwork.com
Importance Bariatric surgery is beneficial in persons with a body mass index (BMI) of 35 or
greater with obesity-related comorbidities. There is interest in using these procedures in …

The Diabetes Surgery Summit consensus conference: recommendations for the evaluation and use of gastrointestinal surgery to treat type 2 diabetes mellitus

F Rubino, LM Kaplan, PR Schauer… - Annals of …, 2010 - journals.lww.com
Objectives: To develop guidelines for the use of gastrointestinal surgery to treat type 2
diabetes and to craft an agenda for further research. Background: Increasing evidence …

Is type 2 diabetes an operable intestinal disease? A provocative yet reasonable hypothesis

F Rubino - Diabetes care, 2008 - Am Diabetes Assoc
Type 2 diabetes, which accounts for 90–95% of all cases of diabetes, is a growing epidemic
that places a severe burden on health care systems, especially in developing countries …

Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes

DM Breen, BA Rasmussen, A Kokorovic, R Wang… - Nature medicine, 2012 - nature.com
Gastrointestinal bypass surgeries restore metabolic homeostasis in patients with type 2
diabetes and obesity, but the underlying mechanisms remain elusive. Duodenal-jejunal …