[HTML][HTML] Dengue virus infection–a review of pathogenesis, vaccines, diagnosis and therapy

BH Kok, HT Lim, CP Lim, NS Lai, CY Leow, CH Leow - Virus research, 2023 - Elsevier
The transmission of dengue virus (DENV) from an infected Aedes mosquito to a human,
causes illness ranging from mild dengue fever to fatal dengue shock syndrome. The similar …

Dengue fever: causes, complications, and vaccine strategies

N Khetarpal, I Khanna - Journal of immunology research, 2016 - Wiley Online Library
Dengue is a highly endemic infectious disease of the tropical countries and is rapidly
becoming a global burden. It is caused by any of the 4 serotypes of dengue virus and is …

Immunoinformatics design of a novel epitope-based vaccine candidate against dengue virus

AO Fadaka, NRS Sibuyi, DR Martin, M Goboza… - Scientific reports, 2021 - nature.com
Dengue poses a global health threat, which will persist without therapeutic intervention.
Immunity induced by exposure to one serotype does not confer long-term protection against …

Novel approaches for the design, delivery and administration of vaccine technologies

J Wallis, DP Shenton, RC Carlisle - Clinical & Experimental …, 2019 - academic.oup.com
It is easy to argue that vaccine development represents humankind's most important and
successful endeavour, such is the impact that vaccination has had on human morbidity and …

Controlled human infection models to accelerate vaccine development

RKM Choy, AL Bourgeois… - Clinical Microbiology …, 2022 - Am Soc Microbiol
The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …

Dengue: Status of current and under‐development vaccines

M Redoni, S Yacoub, L Rivino… - Reviews in medical …, 2020 - Wiley Online Library
Dengue is an emerging mosquito‐borne viral infection with increasing reports of outbreaks.
The clinical picture ranges from a benign febrile illness through to severe and potentially …

A tetravalent sub-unit dengue vaccine formulated with ionizable cationic lipid nanoparticle induces significant immune responses in rodents and non-human primates

G Swaminathan, EA Thoryk, KS Cox, JS Smith… - Scientific reports, 2016 - nature.com
Dengue virus has emerged as an important arboviral infection worldwide. As a complex
pathogen, with four distinct serotypes, the development of a successful Dengue virus …

Challenges in dengue vaccines development: pre-existing infections and cross-reactivity

AM Izmirly, SO Alturki, SO Alturki, J Connors… - Frontiers in …, 2020 - frontiersin.org
Dengue is one of the most frequently transmitted mosquito-borne diseases in the world,
which creates a significant public health concern globally, especially in tropical and …

Recent developments in recombinant protein–based dengue vaccines

NK Tripathi, A Shrivastava - Frontiers in immunology, 2018 - frontiersin.org
Recombinant proteins are gaining enormous importance these days due to their wide
application as biopharmaceutical products and proven safety record. Various recombinant …

Safety and immunogenicity of one versus two doses of Takeda's tetravalent dengue vaccine in children in Asia and Latin America: interim results from a phase 2 …

X Sáez-Llorens, V Tricou, D Yu, L Rivera… - The Lancet Infectious …, 2017 - thelancet.com
Background Dengue is the most common mosquito-borne viral disease in human beings,
and vector control has not halted its spread worldwide. A dengue vaccine for individuals …