Immunization is a cornerstone of public health policy and is demonstrably highly cost-
effective when used to protect child health. Although it could be argued that immunology has …

The use of antibiotics has enabled the successful treatment of bacterial infections, saving the
lives and improving the health of many patients worldwide. However, the emergence and …

Background Efforts to quantify the global burden of enteric fever are valuable for
understanding the health lost and the large-scale spatial distribution of the disease. We …

Background Typhoid fever remains a major cause of morbidity and mortality in low-income
and middle-income countries. Vi-tetanus toxoid conjugate vaccine (Vi-TT) is recommended …

The achievements of vaccine research and development bring a hope to our societies that
we may cope with the COVID‐19 pandemic. There are two aspects that should be …

Background In 2017, more than half the cases of typhoid fever worldwide were projected to
have occurred in India. In the absence of contemporary population-based data, it is unclear …

Background Enteric fever is a serious public health concern in many low-income and middle-
income countries. Numerous data gaps exist concerning the epidemiology of Salmonella …

Cell-free protein synthesis systems that can be lyophilized for long-term, non-refrigerated
storage and transportation have the potential to enable decentralized biomanufacturing …

Conjugate vaccines are among the most effective methods for preventing bacterial
infections. However, existing manufacturing approaches limit access to conjugate vaccines …

Abstract Background Salmonella Typhi is a major cause of fever in children in low-and
middle-income countries. A typhoid conjugate vaccine (TCV) that was recently prequalified …