Vasculature-on-a-chip for in vitro disease models

S Kim, W Kim, S Lim, JS Jeon - Bioengineering, 2017 - mdpi.com
Vascularization, the formation of new blood vessels, is an essential biological process. As
the vasculature is involved in various fundamental physiological phenomena and closely …

Microfluidic-based 3D engineered microvascular networks and their applications in vascularized microtumor models

X Wang, Q Sun, J Pei - Micromachines, 2018 - mdpi.com
The microvasculature plays a critical role in human physiology and is closely associated to
various human diseases. By combining advanced microfluidic-based techniques, the …

Strategies and Techniques to Enhance the In Situ Endothelialization of Small-Diameter Biodegradable Polymeric Vascular Grafts

AJ Melchiorri, N Hibino, JP Fisher - Tissue Engineering Part B …, 2013 - liebertpub.com
Due to the lack of success in small-diameter (< 6 mm) prosthetic vascular grafts, a variety of
strategies have evolved utilizing a tissue-engineering approach. Much of this work has …

Differentiation of human pluripotent stem cells into functional endothelial cells in scalable suspension culture

R Olmer, L Engels, A Usman, S Menke, MNH Malik… - Stem cell reports, 2018 - cell.com
Endothelial cells (ECs) are involved in a variety of cellular responses. As multifunctional
components of vascular structures, endothelial (progenitor) cells have been utilized in …

Vascular tissue engineering: biodegradable scaffold platforms to promote angiogenesis

JV Serbo, S Gerecht - Stem cell research & therapy, 2013 - Springer
The ability to understand and regulate human vasculature development and differentiation
has the potential to benefit patients suffering from a variety of ailments, including …

Quaking is a key regulator of endothelial cell differentiation, neovascularization, and angiogenesis

A Cochrane, S Kelaini, M Tsifaki, J Bojdo… - Stem …, 2017 - academic.oup.com
The capability to derive endothelial cell (ECs) from induced pluripotent stem cells (iPSCs)
holds huge therapeutic potential for cardiovascular disease. This study elucidates the …

Enhanced therapeutic neovascularization by CD31-expressing cells and embryonic stem cell-derived endothelial cells engineered with chitosan hydrogel containing …

S Lee, CM Valmikinathan, J Byun, S Kim, G Lee… - Biomaterials, 2015 - Elsevier
Various stem cells and their progeny have been used therapeutically for vascular
regeneration. One of the major hurdles for cell-based therapy is low cell retention in vivo …

Stem cell-derived exosomes potential therapeutic roles in cardiovascular diseases

S Jayaraman, D Gnanasampanthapandian… - Frontiers in …, 2021 - frontiersin.org
Owing to myocardial abnormalities, cardiac ailments are considered to be the major cause
of morbidity and mortality worldwide. According to a recent study, membranous vesicles that …

MicroRNA-199b modulates vascular cell fate during iPS cell differentiation by targeting the notch ligand jagged1 and enhancing VEGF signaling

T Chen, A Margariti, S Kelaini, A Cochrane… - Stem …, 2015 - academic.oup.com
Aims: Recent ability to derive endothelial cells (ECs) from induced pluripotent stem (iPS)
cells holds a great therapeutic potential for personalized medicine and stem cell therapy. We …

Accelerating in Situ Endothelialisation of Cardiovascular Bypass Grafts

ET Goh, E Wong, Y Farhatnia, A Tan… - International journal of …, 2014 - mdpi.com
The patency of synthetic cardiovascular grafts in the long run is synonymous with their ability
to inhibit the processes of intimal hyperplasia, thrombosis and calcification. In the human …