Galectin-3 (Gal-3) regulates basic cellular functions such as cell–cell and cell–matrix
interactions, growth, proliferation, differentiation, and inflammation. It is not surprising …

Galectin-3 is a beta-galactoside-binding mammalian lectin and part of the 15 member
galectin family that are evolutionarily highly conserved. It is the only chimeric protein with a …

The efficacy of cancer immunotherapy is limited, in part, by the multitude of
immunosuppressive mechanisms present within the tumor microenvironment (TME) …

Galectin-3, the only chimera galectin found in vertebrates, is one of the best-studied
galectins. It is expressed in several cell types and is involved in a broad range of …

The presence of T cells in tumors predicts overall survival for cancer patients. However, why
most tumors are poorly infiltrated by T cells is barely understood. T-cell recruitment towards …

A combination therapy approach is required to improve tumor immune infiltration and patient
response to immune checkpoint inhibitors that target negative regulatory receptors. Galectin …

Abstract Galectin-3 (Gal-3) plays important roles in cell proliferation, adhesion,
differentiation, angiogenesis and apoptosis in normal and pathologic tissues. Accumulated …

Obesity-induced diabetes is associated with low-grade inflammation in adipose tissue and
macrophage infiltration of islets. We show that ablation of galectin-3 (Gal-3), a galactoside …

Human Galectin-3 (Gal-3), a β-galactoside-binding protein expressed by tumor cells, has
been reported to act as an immune regulator in antitumor T cells. However, its effect on …

Abstract Background and Aims: Galectin-3 [Gal-3] is an endogenous lectin with a broad
spectrum of immunoregulatory effects: it plays an important role in autoimmune/inflammatory …