Ocular neurodegenerative diseases: interconnection between retina and cortical areas

N Marchesi, F Fahmideh, F Boschi, A Pascale… - Cells, 2021 - mdpi.com
The possible interconnection between the eye and central nervous system (CNS) has been
a topic of discussion for several years just based on fact that the eye is properly considered …

Medical therapy for glaucoma: A review

RJ Casson - Clinical & Experimental Ophthalmology, 2022 - Wiley Online Library
A number of pharmacological targets are exploited to modify the parameters in the
Goldmann equation and reduce the intraocular pressure (IOP). This strategy constitutes the …

[HTML][HTML] Testing drug release from medicated contact lenses: The missing link to predict in vivo performance

AF Pereira-da-Mota, CM Phan, A Concheiro… - Journal of Controlled …, 2022 - Elsevier
Contact lenses (CLs) offer a wide variety of advantages as ocular drug-releasing platforms,
but the feasibility of medicated CL development is constrained by numerous scientific …

Intravitreal injectable hydrogels for sustained drug delivery in glaucoma treatment and therapy

KA Akulo, T Adali, MTG Moyo, T Bodamyali - Polymers, 2022 - mdpi.com
Glaucoma is extensively treated with topical eye drops containing drugs. However, the
retention time of the loaded drugs and the in vivo bioavailability of the drugs are highly …

Looking into the future: Gene and cell therapies for glaucoma

AM Komáromy, KL Koehl, SA Park - Veterinary ophthalmology, 2021 - Wiley Online Library
Glaucoma is a complex group of optic neuropathies that affects both humans and animals.
Intraocular pressure (IOP) elevation is a major risk factor that results in the loss of retinal …

[HTML][HTML] Glaucoma: Novel antifibrotic therapeutics for the trabecular meshwork

M Qin, C Yu-Wai-Man - European Journal of Pharmacology, 2023 - Elsevier
Glaucoma is a chronic and progressive neurodegenerative disease characterized by the
loss of retinal ganglion cells and visual field defects, currently affecting around 1% of the …

Intracameral drug delivery: a review of agents, indications, and outcomes

M Gautam, R Gupta, P Singh, V Verma… - Journal of Ocular …, 2023 - liebertpub.com
An intracameral (IC) injection directly delivers the drug into the anterior chamber of the eye.
This targeted drug delivery technique overcomes the ocular barriers and offers a high …

[HTML][HTML] Progress in drug formulation design and delivery of medicinal substances used in ophthalmology

KB Wroblewska, B Jadach… - International Journal of …, 2021 - Elsevier
Due to the very low bioavailability of drugs administered to the surface of the eyeball, issues
related to the formulation of an ophthalmic drug pose a technological challenge. The …

3D-printed long-acting 5-fluorouracil implant to prevent conjunctival fibrosis in glaucoma

N Ioannou, J Luo, M Qin, M Di Luca… - Journal of Pharmacy …, 2023 - academic.oup.com
Objectives To develop a sustained release 5-fluorouracil (5-FU) implant by three-
dimensional (3D) printing to effectively prevent conjunctival fibrosis after glaucoma surgery …

[HTML][HTML] Drug Delivery Systems for Glaucoma: A Narrative Review

AM Fea, V Vallino, M Cossu, V Marica, C Novarese… - Pharmaceuticals, 2024 - mdpi.com
Glaucoma is one of the world's leading causes of blindness, and its management is
challenging. The main objective is to lower intraocular pressure through medical, para …