Experimental models of Alzheimer's disease (AD) are critical to gaining a better
understanding of pathogenesis and to assess the potential of novel therapeutic approaches …

Alzheimer's disease (AD) pathogenesis is widely believed to be driven by the production
and deposition of the amyloid-β peptide (Aβ). For many years, investigators have been …

Microglia are the primary immune cells of the central nervous system that help nourish and
support neurons, clear debris, and respond to foreign stimuli. Greatly impacted by their …

Alzheimer's disease (AD) is one of the looming health crises of the near future. Increasing
lifespans and better medical treatment for other conditions mean that the prevalence of this …

Humans have evolved much longer lifespans than the great apes, which rarely exceed 50
years. Since 1800, lifespans have doubled again, largely due to improvements in …

Age-related neurodegenerative diseases are largely limited to humans and rarely occur
spontaneously in animals. Genetically engineered mouse models recapitulate aspects of the …

The great apes (chimpanzees, bonobos, gorillas, and orangutans) are our closest relatives.
Despite the many similarities, there are significant differences in aging among apes …

According to the WHO, the proportion of people over 60 years is increasing and expected to
reach 22% of total world's population in 2050. In parallel, recent animal demographic …

The aged dog naturally develops cognitive decline in many different domains (including
learning and memory) but also exhibits human-like individual variability in the aging …

Neurodegenerative diseases present a major and increasing burden in the societies
worldwide. With aging populations, the prevalence of neurodegenerative diseases is …