Numerous observational studies have suggested that there is a correlation between the
level of serum vitamin D and MS risk and disease activity. To explore this hypothesis, a …

Over the last three decades, it has become clear that the role of vitamin D goes beyond the
regulation of calcium homeostasis and bone health. An important extraskeletal effect of …

Beyond its critical function in calcium homeostasis, vitamin D has recently been found to
play an important role in the modulation of the immune/inflammation system via regulating …

The immune system, innate and adaptive, is a highly evolved and complex network,
essential for promoting survival in an environment full of potential pathogens, while …

Background The evidence for vitamin D and other agents that experimentally modulate T
regulatory cells (Tregs) for the treatment of patients with autoimmune or allergic diseases …

Although strong genetic determinants of multiple sclerosis (MS) exist, the findings of
migration studies support a role for environmental factors in this disease. Through rigorous …

Lately, vitamin D has been linked with metabolic and immunological processes, which
established its role as an essential component of human health preservation. Vitamin D has …

Vitamin D deficiency has been associated with the risk of multiple sclerosis, disease activity
and progression. Results from in vitro experiments, animal models and analysis of human …

Vitamin D system comprises hormone precursors, active metabolites, carriers, enzymes, and
receptors involved in genomic and non-genomic effects. In addition to classical bone-related …

Various autoimmune rheumatic diseases (ARDs), including rheumatoid arthritis,
spondyloarthritis, vasculitis and systemic lupus erythematosus, are associated with …