[HTML][HTML] Modulation of immune responses to vaccination by the microbiota: implications and potential mechanisms
The need for highly effective vaccines that induce robust and long-lasting immunity has
never been more apparent. However, for reasons that are still poorly understood, immune …
never been more apparent. However, for reasons that are still poorly understood, immune …
The impact of ageing on monocytes and macrophages
RPH De Maeyer, ES Chambers - Immunology letters, 2021 - Elsevier
Ageing is a global burden. Increasing age is associated with increased incidence of
infections and cancer and decreased vaccine efficacy. This increased morbidity observed …
infections and cancer and decreased vaccine efficacy. This increased morbidity observed …
COVID-19 in Africa: Dampening the storm?
Coronavirus disease 2019 (COVID-19) has spread rapidly and extensively to most countries
in the world, resulting in considerable mortality in Europe and the United States, as well as …
in the world, resulting in considerable mortality in Europe and the United States, as well as …
[HTML][HTML] Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition
Ageing of the global population has become a public health concern with an important socio-
economic dimension. Ageing is characterized by an increase in the concentration of …
economic dimension. Ageing is characterized by an increase in the concentration of …
[HTML][HTML] The impact of the microbiome on immunity to vaccination in humans
Vaccines are the most effective means available for preventing infectious diseases.
However, vaccine-induced immune responses are highly variable between individuals and …
However, vaccine-induced immune responses are highly variable between individuals and …
[HTML][HTML] BCG vaccination in humans inhibits systemic inflammation in a sex-dependent manner
VACM Koeken, LCJ de Bree… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND Induction of innate immune memory, also termed trained immunity, by the
antituberculosis vaccine bacillus Calmette-Guérin (BCG) contributes to protection against …
antituberculosis vaccine bacillus Calmette-Guérin (BCG) contributes to protection against …
[HTML][HTML] Optimize prime/boost vaccine strategies: trained immunity as a new player in the game
JL Palgen, Y Feraoun, G Dzangué-Tchoupou… - Frontiers in …, 2021 - frontiersin.org
Most vaccines require multiple doses to induce long-lasting protective immunity in a high
frequency of vaccines, and to ensure strong both individual and herd immunity. Repetitive …
frequency of vaccines, and to ensure strong both individual and herd immunity. Repetitive …
[HTML][HTML] T-cell activation is an immune correlate of risk in BCG vaccinated infants
HA Fletcher, MA Snowden, B Landry, W Rida… - Nature …, 2016 - nature.com
Vaccines to protect against tuberculosis (TB) are urgently needed. We performed a case–
control analysis to identify immune correlates of TB disease risk in Bacille Calmette–Guerin …
control analysis to identify immune correlates of TB disease risk in Bacille Calmette–Guerin …
Development and deployment of COVID-19 vaccines for those most vulnerable
WC Koff, T Schenkelberg, T Williams… - Science translational …, 2021 - science.org
Development of safe and effective COVID-19 vaccines is a global priority and the best hope
for ending the COVID-19 pandemic. Remarkably, in less than 1 year, vaccines have been …
for ending the COVID-19 pandemic. Remarkably, in less than 1 year, vaccines have been …
[HTML][HTML] Targeting inflammation and immunosenescence to improve vaccine responses in the elderly
B Pereira, XN Xu, AN Akbar - Frontiers in immunology, 2020 - frontiersin.org
One of the most appreciated consequences of immunosenescence is an impaired response
to vaccines with advanced age. While most studies report impaired antibody responses in …
to vaccines with advanced age. While most studies report impaired antibody responses in …