This article presents an overview of time-resolved (lifetime) fluorescence techniques used in
biomedical diagnostics. In particular, we review the development of time-resolved …

When light is incident to a biological tissue surface, combinations of optical processes occur,
such as reflection, absorption, elastic and non-elastic scattering, and fluorescence. Analysis …

A series of fluorophores with single-exponential fluorescence decays in liquid solution at 20°
C were measured independently by nine laboratories using single-photon timing and …

The study of biological systems in their real environmental conditions is crucial to decipher
the true image of structures and processes underlying their functionality. In this regard …

Avalanche photodiodes (APDs) operating in Geiger mode can detect weak optical signals at
high speed. The implementation of APD systems in a CMOS technology makes it possible to …

There is an ever-increasing demand for new imaging methods that can provide additional
information about the coronary wall to better characterize and stratify high-risk plaques, and …

Fluorescence lifetime imaging (FLIm) is an optical spectroscopic imaging technique capable
of real‐time assessments of tissue properties in clinical settings. Label‐free FLIm is sensitive …

This study evaluates the potential of time-resolved laser induced fluorescence spectroscopy
(TR-LIFS) as intra-operative tool for the delineation of brain tumor from normal brain. Forty …

The goal of this study is to determine the potential of time-resolved laser-induced
fluorescence spectroscopy (TR-LIFS) as an adjunctive tool for delineation of brain tumor …

The autofluorescence of biological tissue can be exploited for the detection and diagnosis of
disease but, to date, its complex nature and relatively weak signal levels have impeded its …