Portal vein thrombosis (PVT) represents a well-known complication during the natural
course of liver cirrhosis (LC), ranging from asymptomatic cases to life-threating conditions …

The societal burden of Alzheimer's disease (AD) is staggering, with current estimates
suggesting that 50 million people world-wide have AD. Identification of new therapeutic …

Abstract Background and Aims Direct oral anticoagulants (DOAC) are important new
anticoagulant therapies that are not well studied in patients with chronic liver disease. The …

Obesity promotes a chronic inflammatory and hypercoagulable state that drives
cardiovascular disease, type 2 diabetes, fatty liver disease, and several cancers. Elevated …

Simple Summary Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver
disease affecting a quarter of the global population and carries the risk of developing …

Activation of the blood coagulation cascade leads to fibrin deposition and platelet activation
that are required for hemostasis. However, aberrant activation of coagulation can lead to …

Platelets are one of the key mediators in thrombosis as well as in the progression of many
diseases. An increase in platelet activation and a decrease in platelet count is associated …

The deleterious effects of diabetes in the heart are increasingly attributed to inflammatory
signaling through the NLRP3 (NOD, LRR and PYD domains-containing protein 3) …

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and it is
anticipated that it could become even more prevalent in parallel with an increase in the …

Acute and chronic liver disease are associated with substantial alterations in the hemostatic
system. Evidence from both experimental and clinical studies suggests that anticoagulants …