[HTML][HTML] YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth
Organ size is controlled by the concerted action of biochemical and physical processes.
Although mechanical forces are known to regulate cell and tissue behavior, as well as …
Although mechanical forces are known to regulate cell and tissue behavior, as well as …
Emerging roles of TEAD transcription factors and its coactivators in cancers
AV Pobbati, W Hong - Cancer biology & therapy, 2013 - Taylor & Francis
TEAD proteins are transcription factors that are crucial for development, but also play a role
in cancers. Several developmentally and pathologically important genes are upregulated by …
in cancers. Several developmentally and pathologically important genes are upregulated by …
Zinc-dependent regulation of ZEB1 and YAP1 coactivation promotes epithelial-mesenchymal transition plasticity and metastasis in pancreatic cancer
Background Pancreatic cancer is characterized by extensive metastasis. Epithelial-
mesenchymal transition (EMT) plasticity plays a critical role in tumor progression and …
mesenchymal transition (EMT) plasticity plays a critical role in tumor progression and …
[HTML][HTML] A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer
The Hippo pathway has been implicated in suppressing tissue overgrowth and tumor
formation by restricting the oncogenic activity of YAP. However, transcriptional regulators …
formation by restricting the oncogenic activity of YAP. However, transcriptional regulators …
[HTML][HTML] Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry
X Feng, MS Degese, R Iglesias-Bartolome, JP Vaque… - Cancer cell, 2014 - cell.com
Mutually exclusive activating mutations in the GNAQ and GNA11 oncogenes, encoding
heterotrimeric Gαq family members, have been identified in∼ 83% and∼ 6% of uveal and …
heterotrimeric Gαq family members, have been identified in∼ 83% and∼ 6% of uveal and …
[HTML][HTML] Fluid shear stress activates YAP1 to promote cancer cell motility
HJ Lee, MF Diaz, KM Price, JA Ozuna, S Zhang… - Nature …, 2017 - nature.com
Mechanical stress is pervasive in egress routes of malignancy, yet the intrinsic effects of
force on tumour cells remain poorly understood. Here, we demonstrate that frictional force …
force on tumour cells remain poorly understood. Here, we demonstrate that frictional force …
Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor survival rates
and frequently carries oncogenic KRAS mutation. However, KRAS has thus far not been a …
and frequently carries oncogenic KRAS mutation. However, KRAS has thus far not been a …
[HTML][HTML] Macrophage K63-linked ubiquitination of YAP promotes its nuclear localization and exacerbates atherosclerosis
M Liu, M Yan, H Lv, B Wang, X Lv, H Zhang, S Xiang… - Cell reports, 2020 - cell.com
Summary The Hippo/Yes-associated protein (YAP) pathway has pivotal roles in innate
immune responses against pathogens in macrophages. However, the role of YAP in …
immune responses against pathogens in macrophages. However, the role of YAP in …
[HTML][HTML] The YAP/TAZ pathway in osteogenesis and bone sarcoma pathogenesis
H Kovar, L Bierbaumer, B Radic-Sarikas - Cells, 2020 - mdpi.com
YAP and TAZ are intracellular messengers communicating multiple interacting extracellular
biophysical and biochemical cues to the transcription apparatus in the nucleus and back to …
biophysical and biochemical cues to the transcription apparatus in the nucleus and back to …
The Hippo pathway and YAP/TAZ–TEAD protein–protein interaction as targets for regenerative medicine and cancer treatment: Miniperspective
The Hippo pathway is an important organ size control signaling network and the major
regulatory mechanism of cell-contact inhibition. Yes associated protein (YAP) and …
regulatory mechanism of cell-contact inhibition. Yes associated protein (YAP) and …