Significance: Organisms adapt to changing environments by engaging cellular stress
response pathways that serve to restore proteostasis and enhance survival. A primary …

Mitochondria are the only organelles regulated by two genomes. The coordinated
translation of nuclear DNA (nDNA) and mitochondrial DNA (mtDNA), which together co …

Translation of 5′ terminal oligopyrimidine (TOP) mRNAs encoding the protein synthesis
machinery is strictly regulated by an amino-acid-sensing mTOR pathway. However, its …

A central mechanism of mTOR complex 1 (mTORC1) signaling is the coordinated translation
of ribosomal protein and translation factor mRNAs mediated by the 5′-terminal …

In all domains of life, mechanisms exist that adjust translational capacity to nutrient
restriction and other growth constraints. The mammalian target of rapamycin (mTOR) …

Pre‐existing but untranslated or 'poised'mRNA exists as a means to rapidly induce the
production of specific proteins in response to stimuli and as a safeguard to limit the actions …

Vertebrate cells have evolved a simple, yet elegant, mechanism for coordinated regulation
of ribosome biogenesis mediated by the 5′ terminal oligopyrimidine motif (5′ TOP). This …

Terminal oligopyrimidine motif-containing mRNAs (TOPs) encode all ribosomal proteins in
mammals and are regulated to tune ribosome synthesis to cell state. Previous studies have …

La-related proteins (LARPs) are a family of RNA-binding proteins that share a conserved La
motif (LaM) domain. LARP1 plays a role in regulating ribosomal protein synthesis and …

RNA binding proteins (RBPs) play crucial roles in regulating every stage of the mRNA life
cycle and mediating non-coding RNA functions. Despite their importance, the specific roles …