Sleep–wake disturbances following traumatic brain injury (TBI) are increasingly recognized
as a serious consequence following injury and as a barrier to recovery. Injury-induced sleep …

Sleep-wake disturbances are extremely common after a traumatic brain injury (TBI). The
most common disturbances are insomnia (difficulties falling or staying asleep), increased …

Background: Although fatigue and sleep disturbance are commonly reported following
traumatic brain injury (TBI), understanding of their nature and treatment remains limited …

Modafinil is a wake-promoting agent that is pharmacologically different from other
stimulants. It has been investigated in healthy volunteers, and in individuals with clinical …

Sleep disturbance is common after traumatic brain injury (TBI). Insomnia, fatigue, and
sleepiness are the most frequent post-TBI sleep complaints with narcolepsy (with or without …

Background Fatigue is common after traumatic brain injury (TBI). Its risk factors, natural
history and consequences are uncertain. Best-evidence synthesis was used to address the …

There are numerous disorders of known or presumed neurologic origin that result in
excessive daytime sleepiness, collectively known as the central disorders of …

Pharmacological management of neurobehavioral disorders following traumatic brain injury
(TBI) is common practice. However, the evidence available to guide this practice remains …

Purpose Fatigue is a distressing symptom occurring in more than 60% of patients with
cancer. The CNS stimulants modafinil and methylphenidate are recommended for the …

Traumatic brain injury (TBI) is a major worldwide healthcare problem. Despite promising
outcomes from many preclinical studies, the failure of several clinical studies to identify …