Our ancestral diet consisted of much more nondigestible fiber than that of many societies
today. Thus, from an evolutionary perspective the human genome and its physiological and …

Dietary fibre has long been established as a nutritionally important, health-promoting food
ingredient. Modern dietary practices have seen a significant reduction in fibre consumption …

Colorectal cancer (CRC) is among the most frequent forms of cancer, and new strategies for
its prevention and therapy are urgently needed. Here we identify a metabolite signalling …

The gut microbiota plays an important role in cardio-metabolic diseases with diet being
among the strongest modulators of gut microbiota composition and function. Resistant …

Short-chain fatty acids (SCFAs), particularly acetate, propionate and butyrate, are mainly
produced by anaerobic fermentation of gut microbes. SCFAs play an important role in …

Dynamic interactions between gut microbiota and a host's innate and adaptive immune
systems are essential in maintaining intestinal homeostasis and inhibiting inflammation. Gut …

Short-chain fatty acids (SCFAs), mainly including acetate, propionate, and butyrate, are
metabolites produced during the bacterial fermentation of dietary fiber in the intestinal tract …

The diverse and dynamic microbial community of the human gastrointestinal tract plays a
vital role in health, with gut microbiota supporting the development and function of the gut …

The microbial metabolite butyrate serves as a link between the intestinal microbiome and
epithelium. The monocarboxylate transporters MCT1 and SMCT1 are the predominant …

Following cancer, cells in a particular tissue can no longer respond to the factors involved in
controlling cell survival, differentiation, proliferation, and death. In recent years, it has been …